Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the gorgonian Briareum excavatum

Briarane Diterpenoids Isolated from Gorgonian Corals between 2011 and 2013

“…collected from the coral reef of Ishigaki Island, Okinawa, Japan, were examined. Ten briarane metabolites, including seven new diepoxybriaranes, briaroxalides A–G ( 15 – 21 ) [14] (Table 3), along with three known analogues, brianthein A [15], violide G [16] and briarlide R [17], were isolated. The absolute configurations of 15 – 21 were further confirmed by chemical conversion and X-ray diffraction analysis [14].…”

Step‐Economical Synthesis of Taxol‐like Tricycles through a Palladium‐Catalyzed Domino Reaction

“…[18] Brianthein A is known for reversing multidrug resistance in human carcinoma cell lines. [18] In summary, we have successfully developed a new, concise, and efficient strategy for accessing the taxane tricyclic scaffold. These new tricyclic structures are obtained using two key steps: the first step involves a palladiumcatalyzed domino reaction based on methods previously …”

Step‐Economical Synthesis of Taxol‐like Tricycles through a Palladium‐Catalyzed Domino Reaction

“…Compound 15 represents the basic structure of brianthein A (16), which is a novel brianane-type diterpene recently isolated from the gorgonian Briareum excavatum. [18] Brianthein A is known for reversing multidrug resistance in human carcinoma cell lines. [18] In summary, we have successfully developed a new, concise, and efficient strategy for accessing the taxane tricyclic scaffold.…”

“…[18] Brianthein A is known for reversing multidrug resistance in human carcinoma cell lines. [18] In summary, we have successfully developed a new, concise, and efficient strategy for accessing the taxane tricyclic scaffold. These new tricyclic structures are obtained using two key steps: the first step involves a palladiumcatalyzed domino reaction based on methods previously developed in our research group.…”