Civil infrastructure worldwide is subject to factors such as aging and deterioration. Structural health monitoring (SHM) can be used to assess the impact of these processes on structural performance. SHM demands have evolved from routine monitoring to real-time and autonomous assessment. One of the frontiers in achieving effective SHM systems has been the use of wireless smart sensors (WSSs), which are attractive compared to wired sensors, due to their flexibility of use, lower costs, and ease of long-term deployment. Most WSSs use accelerometers to collect global dynamic vibration data. However, obtaining local behaviors in a structure using measurands such as strain may also be desirable. While wireless strain sensors have previously been developed by some researchers, there is still a need for a high sensitivity wireless strain sensor that fully meets the general demands for monitoring large-scale civil infrastructure. In this paper, a framework for synchronized wireless high-fidelity acceleration and strain sensing, which is commonly termed multimetric sensing in the literature, is proposed. The framework is implemented on the Xnode, a next-generation wireless smart sensor platform, and integrates with the strain sensor for strain acquisition. An application of the multimetric sensing framework is illustrated for total displacement estimation. Finally, the potential of the proposed framework integrated with vision-based measurement systems for multi-point displacement estimation with camera-motion compensation is demonstrated. The proposed approach is verified experimentally, showing the potential of the developed framework for various SHM applications.