Bridging Ayurveda with evidence-based scientific approaches in medicine

Patwardhan, Bhushan

doi:10.1186/1878-5085-5-19

Cited by 135 publications

(71 citation statements)

References 53 publications

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“…[1,18] But, those studies which have focused on elderly age group or have analyzed the CAM usage in patients of diseases such as osteoarthritis and diabetes, where the chances of a patient being elderly is more, have reported the prevalence in the range of 41% to 67%. [12,19] The higher use of CAM in the elderly age group can be understood to be due to the increase in the number of chronic diseases, most of which can only be controlled and not cured in the current therapeutic scenario. It has been found in previous studies that nearly 65% of adults older than 65 years have multiple chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

Use of complementary and alternative medicines in Indian elderly patients

Sharma¹,

Dubey²,

Malhotra³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Use of complementary and alternative medicine (CAM) is more common in elderly patients due to the prevalence of various age-related chronic medical conditions. The pharmacokinetics and pharmacodynamics change with age and are different in the elderly as compared to a young adult. Non-disclosure of CAM usage voluntarily by the patients, along with the practice of poly-pharmacy for various comorbidities and concurrent use of modern medicine with CAM, makes this age group particularly prone to adverse effects of drugs and the drug-drug interactions. Use of CAM assumes further importance in the context of Indian elderly, due to the widespread belief in traditional medicines and easy over-the-counter availability of many prescription drugs in India. Aims and Objective: The study was conducted to understand and analyze the knowledge, attitude, and perception of CAM usage specifically in elderly Indian patients, which to the best of our knowledge has yet not been assessed previously. Materials and Methods: It was a descriptive cross-sectional study assessing a representative sample of 325 elderly patients over the age of 60 years. Data collection was done after face-to-face interview-based survey administered on a semi-structured questionnaire. Results: The number of CAM users (65.5%) was significantly more than the non-users (P ≤ 0.05). In the age group between 60 and 69 years, 59% had used CAM, as compared to a significantly more number of 76% patients (P ≤ 0.05), in the age group above 70 years. The CAM practice in the elderly was not influenced significantly by gender, education, rural or urban background, and distance from the health-care facility of modern medicine system. CAM was the initial choice of therapy for 65.7% of the users. Ayurveda was the most popular practice (64.8%), followed by homeopathy (62.4%) with many patients using both the practices together. Use of CAM practices concomitantly with modern medicine was not considered unsafe by 56.8% of patients. The physicians of modern medicine did not ask 91.5% of elderly patients about CAM usage and 85.5% of patients did not volunteer any information on CAM usage unless asked for. Conclusions: The study suggests the need to acknowledge and explore the high prevalence of CAM usage with increasing age in the Indian elderly, both to identify the irrational usage of CAM alone or in combination with the modern medicine system and to facilitate the integration of rational CAM practices in the mainstream medicine.

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Section: Discussionmentioning

confidence: 99%

Use of complementary and alternative medicines in Indian elderly patients

Sharma¹,

Dubey²,

Malhotra³

et al. 2017

Natl J Physiol Pharm Pharmacol

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“…As much as 251 genes were already found to be differentially expressed between "Prakriti" groups [2]. Probable correlation among genotypic and expression differences versus "Prakriti" phenotypes were postulated by studying gene polymorphisms of CYP2C19, HLA-DRB1 and EGLN1 genes [1][2][3]5,6,11,15,16]. Identifiable differences in allele frequencies of common variations in 14 Single Nucleotide Polymorphisms of five genes (FAS, AKT3, FBN2, EGLN1 and RAD51) were postulated to be a probable predictive marker for differential responsiveness of people belonging to different groups towards environment, drugs and diseases [2,5].…”

Section: Discussionmentioning

confidence: 99%

“…Ayurveda conceives a four-dimensional definition of health (a far more smarter definition than the definition put forward by 'modern medicine') because a balanced condition of somatic and psychic humors ('doshas'), digestive capacity ('agni'), body tissues (' dhatu), excretions ('mala'), kriya (physiological activity) and soundness of soul ('atma'), sensory organs ('indriya'), mind ('mana') actually defines health (' Ayus'). As per this perspective, Ayurveda is concerned with measures to protect health ('ayus') which includes healthy living along with therapeutic measures that relate to physical, mental, social and spiritual harmony [9][10][11]. Understanding the inner harmony of nature ('prakriti') is the philosophical basis of age-old, yet ever-green, medical science of India.…”

Section: Introductionmentioning

confidence: 99%

Genesis of Personalized Medicine: Relevance of Ayurveda in the Present Millennium

Chakraborty¹,

Chakraborty²

2017

J Mol Genet Med

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Deciphering human genome has ushered modern bio-medical science towards a future hope of revitalizing current symptomatic or prophylactic treatment methods into personalized and predictive medicine depending upon an individual's genetic makeup. Genetic variations related to a person's response towards drugs, differential susceptibility to disease and reciprocity of phenotypic attributes related to environment, ethno-racial origin and diseases to genotypes have not been meticulously apprehended yet. Ayurveda, an age-old health science resonated unequivocally with ancient system of classifying a person on the basis of "Prakriti" or unchangeable constitution type might be an advantageous inclination towards personalized medicine, bearing testable molecular and genetic correlates. Several genomic and metabolomic studies augmented the possibilities of yet undisclosed molecular and genetic basis of Ayurveda, which could further be integrated or complemented to current medical diagnosis and treatment. Further deep dive into the extremes of utilizable science and technology of this holistic practice remained quintessential for better enlightenment of future bio-medical science to fight all fiends of ailments.

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“…There is growing support for the 'black-box' approach, i.e., assessing the entire package of interventions rather than individual components, as efficacy is postulated to depend on the synergistic action of various components [169]. Much has been written about the need for newer paradigms for research in Ayurveda and the way forward, and it applies for research on epilepsy too [170][171][172].…”

Section: Future Prospectsmentioning

confidence: 99%