Bridging micro/nano-platform and airway allergy intervention

Sun, Mengjie; Teng, Zhuang; Fan, Peng-Sheng; Chen, Xiguang; Liu, Ya

doi:10.1016/j.jconrel.2021.11.040

Cited by 9 publications

(6 citation statements)

References 214 publications

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“…Allergic airway diseases are characterized by sneezing, itching, wheezing, chest tightness, airway obstruction, and hyperresponsiveness [ 96 ]. After allergen exposure, the number of CD4 + T cells and ILC2s in the lung increases dramatically, with the significant increase of IL-33 expression in the lung [ 97 ].…”

Section: Crosstalk Between Ilc2s and Cd4 + T Cells...mentioning

confidence: 99%

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Guo

2022

Journal of Immunology Research

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Cytokine secretion, such as interleukin-4 (IL-4), IL-5, IL-9, IL-13, and amphiregulin (Areg), by type 2 innate lymphoid cells (ILC2s) is indispensable for homeostasis, remodeling/repairing tissue structure, inflammation, and tumor immunity. Often viewed as the innate cell surrogate of T helper type 2 (Th2) cells, ILC2s not only secrete the same type 2 cytokines, but are also inextricably related to CD4+T cells in terms of cell origin and regulatory factors, bridging between innate and adaptive immunity. ILC2s interact with CD4+T cells to play a leading role in a variety of diseases through secretory factors. Here, we review the latest progress on ILC2s and CD4+T cells in the lung, the close relationship between the two, and their relevance in the lung disease and immunity. This literature review aids future research in pulmonary type 2 immune diseases and guides innovative treatment approaches for these diseases.

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Section: Crosstalk Between Ilc2s and Cd4 + T Cells...mentioning

confidence: 99%

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Guo

2022

Journal of Immunology Research

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“…An in vivo self-assembly strategy, by responding to endogenous trigger factors (enzymes, pH, reactive oxygen species, and ligand–receptor interaction) could obtain a variety of controllable structures, including nanoparticles, nanofibers, and gels, which was capable of displaying retention effect at targeted sites, thereby increasing the accumulation of drugs. − Inspired by this, based on the physiological characteristics of the nasal microenvironment (pH 5–6, 33 °C, lysozyme, etc. ), − developing nanomaterials that can sense these signals and spontaneously form an advanced and ordered assembly structure is expected to achieve their accumulation and retention in the nasal cavity.…”

Section: Introductionmentioning

confidence: 99%

Intranasal Morphology Transformation Nanomedicines for Long-Term Intervention of Allergic Rhinitis

Teng,

Yang,

Chen

et al. 2023

ACS Nano

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“…Airway allergic diseases, mainly asthma (AS) and allergic rhinitis (AR) are a group of chronic inflammatory diseases. Airway allergic diseases' main pathological features are the inflammatory response of the airway mucosa and airway tissue remodeling when individuals are exposed to airborne allergens, resulting in the involvement of multiple immune cells and the release of inflammatory mediators [1][2][3]. In recent years, the prevalence of allergic diseases has increased globally yearly, with the intensification of environmental pollution, which seriously adversely affects people's quality of life and learning [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

Cheng

Tang

Xie

et al. 2022

Mediators of Inflammation

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Allergic rhinitis and asthma are common airway allergic diseases, the incidence of which has increased annually in recent years. The human body is frequently exposed to allergens and environmental irritants that trigger immune and inflammatory responses, resulting in altered gene expression. Mounting evidence suggested that epigenetic alterations were strongly associated with the progression and severity of allergic diseases. Noncoding RNAs (ncRNAs) are a class of transcribed RNA molecules that cannot be translated into polypeptides and consist of three major categories, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Previous studies showed that ncRNAs were involved in the physiopathological mechanisms of airway allergic diseases and contributed to their occurrence and development. This article reviews the current state of understanding of the role of noncoding RNAs in airway allergic diseases, highlights the limitations of recent studies, and outlines the prospects for further research to facilitate the clinical translation of noncoding RNAs as therapeutic targets and biomarkers.

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Bridging micro/nano-platform and airway allergy intervention

Cited by 9 publications

References 214 publications

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Intranasal Morphology Transformation Nanomedicines for Long-Term Intervention of Allergic Rhinitis

The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

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