Bridging the divide between human and environmental nanotoxicology

Malysheva, Anzhela; Lombi, Enzo; Voelcker, Nicolas H.

doi:10.1038/nnano.2015.224

Cited by 69 publications

(47 citation statements)

References 90 publications

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“…The fate of engineered nanoparticles and effect on health following exposure are largely unknown, 1,2 especially in relation to the cardiovascular system. 4 These studies use gold nanoparticles, a commonly used nanoparticle, and one that is being developed for clinical therapeutics.…”

Section: Results and Discussionmentioning

confidence: 99%

Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

Miller¹,

Raftis²,

Langrish³

et al. 2017

ACS Nano

501

287

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The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy. Healthy volunteers were exposed to nanoparticles by acute inhalation, followed by repeated sampling of blood and urine. Gold was detected in the blood and urine within 15 min to 24 h after exposure, and was still present 3 months after exposure. Levels were greater following inhalation of 5 nm (primary diameter) particles compared to 30 nm particles. Studies in mice demonstrated the accumulation in the blood and liver following pulmonary exposure to a broader size range of gold nanoparticles (2–200 nm primary diameter), with translocation markedly greater for particles <10 nm diameter. Gold nanoparticles preferentially accumulated in inflammation-rich vascular lesions of fat-fed apolipoproteinE-deficient mice. Furthermore, following inhalation, gold particles could be detected in surgical specimens of carotid artery disease from patients at risk of stroke. Translocation of inhaled nanoparticles into the systemic circulation and accumulation at sites of vascular inflammation provides a direct mechanism that can explain the link between environmental nanoparticles and cardiovascular disease and has major implications for risk management in the use of engineered nanomaterials.

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Section: Results and Discussionmentioning

confidence: 99%

Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

Miller¹,

Raftis²,

Langrish³

et al. 2017

ACS Nano

501

287

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“…The rapid development of nanomaterials has led to an increase in the number and variety of engineered nanoparticles in the environment [1][2][3][4]. We are continuously exposed to products containing engineered nanomaterials (ENMs).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle–membrane interactions

Contini

Schneemilch

Gaisford

et al. 2017

Journal of Experimental Nanoscience

154

109

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Engineered nanomaterials have a wide range of applications and as a result, are increasingly present in the environment. While they offer new technological opportunities, there is also the potential for adverse impact, in particular through possible toxicity. In this review, we discuss the current state of the art in the experimental characterisation of nanoparticle-membrane interactions relevant to the prediction of toxicity arising from disruption of biological systems. One key point of discussion is the urgent need for more quantitative studies of nano-bio interactions in experimental models of lipid system that mimic in vivo membranes.

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“…It has six major steps: (1) destruction of the peptidoglycan layer, (2) release of toxic metal ions, (3) alteration of proton efflux pumps, (4) generation of free radicals, (5) damage to the genetic material, and (6) reduction of ATP production. sunscreen preparations; (2) occupational exposuredfor workers in nanomaterial manufacturing and research; (3) environmental exposuredthe increasing concentrations of nanomaterials in groundwater and soil may produce a significant environmental risk (Malysheva et al, 2015). Moreover, the toxicity of nanomaterials is broadly classified into two areas:…”

Section: Nanotoxicologymentioning

confidence: 99%