Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

Hsieh, Kuangwen; Melendez, Johan H.; Gaydos, Charlotte A.; Wang, Jeff Tza-Huei

doi:10.1039/d1lc00665g

Cited by 20 publications

(19 citation statements)

References 339 publications

(439 reference statements)

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“…11 Thus, more comprehensive STI treatment programs are needed, especially as point-of-care STI diagnostics are developed and disseminated. 12,13 STIs are particularly concerning among pregnant women and women planning for pregnancy, since untreated STIs can cause significant neonatal morbidity and mortality. 14,15 STI management in pregnancy is perhaps most pressing in sub-Saharan Africa because this region carries the highest, global, fertility rates in addition to having the highest STI incidence and HIV prevalence.…”

Section: Introductionmentioning

confidence: 99%

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STI prevalence, incidence, and partner notification among women in a periconception HIV prevention program in Uganda

et al. 2022

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Background We provided sexually transmitted infection (STI) screening and facilitated partner notification and treatment among women participating in a periconception HIV prevention program in southwestern Uganda to understand follow-up STI incidence. Methods Women at-risk for HIV exposure while planning for pregnancy completed laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis at enrollment and 6 months of follow-up and/or incident pregnancy; facilitated partner notification and treatment were offered for those with positive tests. We performed a logistic regression to determine correlates of follow-up STI. Results Ninety-four participants completed enrollment STI screening with a median age of 29 (IQR 26–34); 23 (24%) had ≥1 STI. Of the 23 participants with enrollment STI(s), all completed treatment and 19 (83%) returned for follow-up; 18 (78%) reported delivering partner notification cards and discussing STIs with partner(s), and 14 (61%) reported all partners received STI treatment. Of the 81 (86%) who successfully completed follow-up STI screening, 17 (21%) had ≥1 STI. The STI incidence rate was 29.0 per 100 person-years. In univariable regression analysis, enrollment STI, younger age, less education, and alcohol consumption were all significantly associated with follow-up STI. Conclusions We demonstrated high enrollment and follow-up STI rates and moderate participant-reported partner treatment among women planning for pregnancy in Uganda despite partner notification and treatment. Novel STI partner notification and treatment interventions are needed to decrease the STI burden, especially among women planning for and with pregnancy.

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Section: Introductionmentioning

confidence: 99%

“…11 Thus, more comprehensive STI treatment programs are needed, especially as point-of-care STI diagnostics are developed and disseminated. 12,13…”

Section: Introductionmentioning

confidence: 99%

STI prevalence, incidence, and partner notification among women in a periconception HIV prevention program in Uganda

et al. 2022

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“…Still, it involves subgroups with distinct origins, different signs and symptoms, distinct gene abnormalities, different biochemical habits and specific projections. Finally, the clinical study centred primarily on improving the treatment of subtype therapies or on the best means of decreasing the mortality of ovarian cancers was less emphasized (Hsieh et al, 2021).…”

Section: Background Ovarian Cancer Area Using Internet Of Medical Thingsmentioning

confidence: 99%

Feature optimization and identification of ovarian cancer using internet of medical things

Ghazal

Taleb

2022

Expert Systems

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Ovarian cancer (OC) is one kind of tumour that impacts women's ovaries and is hard to diagnose in the initial phase as a primary cause of cancer death. The ovarian cancer information generated by the Clinical Network has been used, and the Self Organizing Map (SOM) and Optimized Neural Networks have suggested a new method for the distinction between ovarian cancer and remaining cancer. Feature optimization and identification of the ovarian cancer (FOI-OV) framework are proposed in this research. The SOM algorithm has also been used separately to improve the functional subset, with understandable and intriguing information from participants' health information steps. The SOM-based collection appears to be tolerable in guided learning strategies due to the lack of different classifiers, which would direct the quest for knowledge specific to the classification algorithm. The classification technique will classify data from ovarian cancer as benign/malignant. By optimizing Neural Network configuration, Advanced Harmony Searching Optimization (AHSO) can enhance the ovarian cancer detection method compared with other methods. This research's suggested model can also diagnose cancer with high precision, and low root means square error (RMSE) early. With 94% precision and 0.029%, RMSE, SOM, and NN techniques have shown identification and precision in ovarian cancer. Optimization (AHSO) has provided an efficient classification approach with a better failure rate.

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“…15–17 Therefore, designing a real-time PCR system with ultra-fast and high sensitivity is an urgent problem. 18–21…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] Therefore, designing a real-time PCR system with ultra-fast and high sensitivity is an urgent problem. [18][19][20][21] Rapid real-time PCR systems generally include biological reaction vectors and real-time PCR devices, which many researchers have intensively studied, and some commercial products have appeared on the market. Timothée Houssin et al achieved heating and cooling of biological reagents inside the PCR chamber by controlling the passage of two different temperature-preheating liquids alternately on the surface of a microfluidic chip, equipped with a fluorescence detection module to complete 30 PCR cycles of nucleic acid amplification and detection within 7 min.…”

Section: Introductionmentioning

confidence: 99%

Ultra-fast, sensitive and low-cost real-time PCR system for nucleic acid detection

Huang,

An,

et al. 2023

Lab Chip

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Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

Abstract: The rate of sexually transmitted infections (STIs), including the four major curable STIs – chlamydia, gonorrhea, trichomoniasis and, syphilis – continue to increase globally, causing medical cost burden and morbidity...

Cited by 20 publications

References 339 publications

STI prevalence, incidence, and partner notification among women in a periconception HIV prevention program in Uganda

STI prevalence, incidence, and partner notification among women in a periconception HIV prevention program in Uganda

Feature optimization and identification of ovarian cancer using internet of medical things

Ultra-fast, sensitive and low-cost real-time PCR system for nucleic acid detection

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