Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

Zhou, Qian; Li, Huimei; Liao, Zhijun; Gao, Bing; He, Bingfang

doi:10.1021/acs.analchem.2c01895

Cited by 16 publications

(7 citation statements)

References 78 publications

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“…[123][124][125] The biomedical applications of microneedles on wound healing and monitoring are also extensively discussed. [126][127] The tremendous potential of microneedle-based devices with therapeutic functions would be able to answer many desires arising for allin-one theranostic systems, which can bridge the gap between wearable sensing bioelectronics and the next-generation healthcare platforms. Therefore, recent advances in therapeutic microneedles are highlighted in the section.…”

Section: Therapeutic Microneedle-based Healthcare Platformsmentioning

confidence: 99%

Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

Sun

Zheng

Shi

et al. 2023

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The rapid development of wearable biosensing calls for next‐generation devices that allow continuous, real‐time, and painless monitoring of health status along with responsive medical treatment. Microneedles have exhibited great potential for the direct access of dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies of microneedle‐based devices have evolved from conventional off‐line detection to multiplexed, wireless, and integrated sensing. In this review, the classification and fabrication techniques of microneedles are first introduced, and then the representative examples of microneedles for transdermal monitoring with different sensing modalities are summarized. State‐of‐the‐art advances in therapeutic and closed‐loop systems are presented to formulate guidelines for the development of next‐generation microneedle‐based healthcare platforms. The potential challenges and prospects are discussed to pave a new avenue toward pragmatic applications in the real world.

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Section: Therapeutic Microneedle-based Healthcare Platformsmentioning

confidence: 99%

Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

Sun

Zheng

Shi

et al. 2023

Small

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“…17 Moreover, it is an anisotropic crystal material whose characteristics depend on the relative orientation of the crystal lattice, yielding different elastic modulus values ranging from 50 to 180 GPa. 18 Thus, in some cases, silicon can exhibit an elastic modulus comparable to that of the metals used in orthopedic implants, and its considerable mechanical strength enables MNs to successfully pierce the skin and promote transdermal drug delivery. The earliest silicon MN was obtained by Henry et al through reactive ion etching micromachining technology.…”

Section: Different Kinds Of Mn Materialsmentioning

confidence: 99%

Modern microelectronics and microfluidics on microneedles

Han,

Li,

Chen

et al. 2023

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“…[ 23,24] Hydrogel Biocompatible and suitable for dry wounds It is only applied to the surface of the wound [25,26] Microneedle Painless, transdermal delivery Limited drug loading [27,28] them 3D printable is the main challenge. In addition, materials should have great mechanical properties and be durable enough to pierce the skin without folding, breaking, or failing.…”

Section: D Printing Technologymentioning

confidence: 99%

Functional Microneedle Patch for Wound Healing and Biological Diagnosis and Treatment

Wang,

Zong,

et al. 2023

Macromolecular Bioscience

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Wound healing, especially chronic wounds, has been one of the major challenges in the field of biomedicine. Drug therapy alone is not effective, so a variety of functional wound healing dressings have been developed. Microneedles have attracted more and more attentions in the field of wound healing dressings due to their penetration and high drug delivery efficiency. In this review, all the studies on the application of microneedles in wound healing in recent years are summarized, classify different microneedles according to their functions in the process of wound healing, discuss the current challenges in the transformation of microneedle technology toward clinical applications, and finally look forward to the future design and development directions of microneedles in this field.

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Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

Cited by 16 publications

References 78 publications

Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

Modern microelectronics and microfluidics on microneedles

Functional Microneedle Patch for Wound Healing and Biological Diagnosis and Treatment

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