2018
DOI: 10.1002/ajp.22756
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Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Abstract: Oxytocin (OT), a neuropeptide that acts in the brain as a neuromodulator, has been long known to shape maternal physiology and behavior in mammals, however its role in regulating social cognition and behavior in primates has come to the forefront only in the recent decade. Many of the current perspectives on the role of OT in modulating social behavior emerged first from studies in rodents, where invasive techniques with a high degree of precision have permitted the mechanistic dissection of OT-related behavio… Show more

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Cited by 26 publications
(33 citation statements)
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References 143 publications
(193 reference statements)
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“…A further limitation is that the operant choice behavior was different for the two monkeys, and we were not able to include the dimensionality analyses of the neural responses to choice behaviors. Finally, the null effect of oxytocin administration adds to the growing evidence that the behavioral and neural effects of intranasal oxytocin in primates has not been unequivocally established (for review, see Putnam et al, 2018). Indeed, in humans and nonhuman primates, the large genetic and behavioral variation among individuals hinders the emergence of reliably replicable responses to oxytocin.…”
Section: Discussionmentioning
confidence: 99%
“…A further limitation is that the operant choice behavior was different for the two monkeys, and we were not able to include the dimensionality analyses of the neural responses to choice behaviors. Finally, the null effect of oxytocin administration adds to the growing evidence that the behavioral and neural effects of intranasal oxytocin in primates has not been unequivocally established (for review, see Putnam et al, 2018). Indeed, in humans and nonhuman primates, the large genetic and behavioral variation among individuals hinders the emergence of reliably replicable responses to oxytocin.…”
Section: Discussionmentioning
confidence: 99%
“…The NBM provides cholinergic input to the entire cortex 63 as well as the amygdala and other regions of the social brain (see Fig. 5 in the recent review by Putnam et al 64 for an anatomical model of NBM connectivity to social neural networks). Based on this connectivity of the NBM, we and others have postulated that OXT acting at OXTR in the NBM could modulate the activity of an extensive network of brain areas (which may themselves lack OXTR) and influence social behavioral processes like social visual attention, gaze direction, and social decision making 38 , 39 , 64 , 65 .…”
Section: Discussionmentioning
confidence: 99%
“…5 in the recent review by Putnam et al 64 for an anatomical model of NBM connectivity to social neural networks). Based on this connectivity of the NBM, we and others have postulated that OXT acting at OXTR in the NBM could modulate the activity of an extensive network of brain areas (which may themselves lack OXTR) and influence social behavioral processes like social visual attention, gaze direction, and social decision making 38 , 39 , 64 , 65 . Indeed, emerging evidence from rhesus macaques indicates that OXT injected site specifically into the rhesus macaque NBM affects social attention, as well as neural activity in the amygdala 66 .…”
Section: Discussionmentioning
confidence: 99%
“…These axonal fibers appear beaded due to varicosities (sites of neurotrans-mitter release). Release from varicosities of these fibers with en passant boutons, rather than classic axo-dendritic synapses, could be the mechanism by which OT and AVP modulate cortical activity (Grinevich & Charlet, 2017; Putnam, Young, & Gothard, 2018), similar to serotonin and catecholamine innervation of the cortex. Axonal release of a single vesicle of OT is estimated to be sufficient for 50% occupancy of OT receptors within a 55 μm radius (Chini et al, 2017).…”
Section: Discussionmentioning
confidence: 99%