Bridging the gap between statistical significance and clinical relevance: A systematic review of minimum clinically important difference (MCID) thresholds of scales reported in movement disorders research

Mishra, Biswamohan; Sudheer, Pachipala; Rajan, Roopa; Agarwal, Ayush; Srivastava, M V Padma; Nilima, Nilima; Vishnu, Venugopalan Y.

doi:10.1016/j.heliyon.2024.e26479

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…The improvements noted in the MDS-UPDRS parts I–IV and total score for several participants (regardless of group allocation) exceeded the minimal clinically important difference (MCID), indicating that these participants may have experienced considerable functional gains after the program ( Mishra et al, 2024 ). Several participants were able to exceed the cutoff of 18 points on the DGI for safe ambulation, while three participants exceeded the threshold for fall risk on the FAB.…”

Section: Discussionmentioning

confidence: 98%

Comparison of externally and internally guided dance movement to address mobility, cognition, and psychosocial function in people with Parkinson’s disease and freezing of gait: a case series

Abraham,

Hart,

Bozzorg

et al. 2024

Front. Aging Neurosci.

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ObjectiveThe aim of this study is to explore the impact of internally guided (IG) versus externally guided (EG) adapted tango (AT) dance training (i.e., dancing the IG “Leader” role or the EG “Follower” role), on motor and non-motor functions in individuals with Parkinson’s disease and freezing of gait (PD-FOG). The “Leader” role, a proxy for IG movements, conveys direction, timing, and amplitude of steps with tactile cues. The “Follower” role, a proxy for EG movements, detects and responds to the leader’s tactile cues.Case descriptionSix participants were randomly assigned to the IG (“Leader”) or EG (“Follower”) roles for 20, 90-min AT lessons over 12 weeks. Participants were assessed for PD-specific and non-PD-specific functions before and twice after the end of the 12-week intervention, at 1-week and 1-month post-intervention.ResultsEG participants improved and/or maintained performance on more outcomes across all domains than IG participants. Five participants improved in PD motor symptoms, dynamic gait, global cognitive function, and the FOG Questionnaire immediately or 1 month after intervention. All participants expressed positive attitudes toward the intervention, including improvements in walking, balance, and endurance.ConclusionAT training in the follower role may benefit individuals with PD-FOG to a greater extent compared to the leader role.ImpactThis case series study could inform additional research with the goal of enhancing physical therapy or music-based therapy approaches for addressing PD-FOG.

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Section: Discussionmentioning

confidence: 98%

Comparison of externally and internally guided dance movement to address mobility, cognition, and psychosocial function in people with Parkinson’s disease and freezing of gait: a case series

Abraham,

Hart,

Bozzorg

et al. 2024

Front. Aging Neurosci.

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L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Ishihara,

Tada,

Kanemitsu

et al. 2024

eClinicalMedicine

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Beyond statistical significance: Embracing minimal clinically important difference for better patient care

Jeyaraman,

Ramasubramanian

et al. 2025

World J Methodol

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The minimal clinically important difference (MCID) represents a pivotal metric in bridging the gap between statistical significance and clinical relevance, addressing the direct impact of medical interventions from the patient's perspective. This comprehensive review analyzes the evolution, applications, and challenges of MCID across medical specialties, emphasizing its necessity in ensuring that clinical outcomes not only demonstrate statistical significance but also offer genuine clinical utility that aligns with patient expectations and needs. We discuss the evolution of MCID since its inception in the 1980s, its current applications across various medical specialties, and the methodologies used in its calculation, highlighting both anchor-based and distribution-based approaches. Furthermore, the paper delves into the challenges associated with the application of MCID, such as methodological variability and the interpretation difficulties that arise in clinical settings. Recommendations for the future include standardizing MCID calculation methods, enhancing patient involvement in setting MCID thresholds, and extending research to incorporate diverse global perspectives. These steps are critical to refining the role of MCID in patient-centered healthcare, addressing existing gaps in methodology and interpretation, and ensuring that medical interventions lead to significant, patient-perceived improvements.

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Bridging the gap between statistical significance and clinical relevance: A systematic review of minimum clinically important difference (MCID) thresholds of scales reported in movement disorders research

Cited by 3 publications

References 87 publications

Comparison of externally and internally guided dance movement to address mobility, cognition, and psychosocial function in people with Parkinson’s disease and freezing of gait: a case series

Comparison of externally and internally guided dance movement to address mobility, cognition, and psychosocial function in people with Parkinson’s disease and freezing of gait: a case series

L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Beyond statistical significance: Embracing minimal clinically important difference for better patient care

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