Brief about hallmarks of aging

Geroscience and Alzheimer’s Disease Drug Development

“…Success in the development of anti-amyloid monoclonal antibodies has focused the field on amyloid as a target for disease modifying therapies (DMTs) ( 4 , 5 ). Studies of the biology of aging have embraced a wider set of biological factors including stem cell exhaustion, epigenetic alterations, deregulated proteostasis, cellular senescence, mitochondrial dysfunction, inflammation, macromolecular damage, and adaptation to stress, many identified as the hallmarks of aging ( 6 – 9 ). The AD drug development pipeline is diversified and has agents targeting a variety of these age-associated biological processes ( 10 ).…”