Using reanalysis data, observations, and seasonal forecasts, the March Arctic ozone loss events in 1997, 2011, and 2020 and their predictability are compared. All of the three ozone loss events were accompanied by an extremely strong and cold polar vortex, with the shape and centroid of the ozone loss controlled by the polar vortex. The high autocorrelation of the March Arctic ozone at a lead/lag time of 1-2 months from observations might suggest that a reasonable prediction can be obtained if one initializes 1-2 months in advance. Based on the chemical scheme assessment in CFSv2 and several empirical models using the forecasted metric(s) of the stratospheric polar vortex as predictor(s), the predictability of the 2011 ozone loss event is shown to be longer (1-2 months) than the other two (~1 month), possibly due to a moderate La Niña and quasi-biennial oscillation westerly winds favorable for the formation of a strong polar vortex. However, the overall predictive skills of ozone from empirical models (using a forecasted substitute index to forecast the Arctic ozone) during 1982-2020 are lower than the chemical module assessment in the forecast system, though empirical models have some skill. Contrary to the ozone predictions, the lower tropospheric temperature pattern in March 2011 is less reasonable than in 1997 and 2020. Similar conclusions are also true in other years (2005 versus 2016). Those findings might indicate a weak relationship between the Arctic ozone and the surface climate in the Northern Hemisphere. Plain Language Summary Extremely low ozone concentrations (or an "ozone hole") develop in the Antarctic every austral spring in present-day atmospheric burdens of ozone-depleting substances. However, similar ozone losses are not observed in the Arctic, though in 1997, 2011, and 2020, ozone loss locally approached that in the Antarctic. This study focuses on the meteorological conditions and predictability for those Arctic ozone loss events. All of the three historical ozone loss events were related to a stratospheric circulation system encircling North Pole (i.e., the stratospheric polar vortex). The shape and centroid of the ozone losses were also controlled by the polar vortex: the ozone loss in March 2020 was displaced toward the North American sector, the March 2011 ozone loss was centered over the North Pole, while the 1997 ozone loss was displaced toward the Eurasian sector. Using the chemical scheme in a seasonal forecasting model and/or empirical models, the lead times for forecasting the three ozone loss events are different due to the tropical forcing. The moderate cold state in the tropical Pacific (i.e., La Niña) and westerly winds in the equatorial stratosphere (i.e., westerly QBO) propel the predictability of the 2011 ozone loss event to around 1-2 months, while the 1997 and 2020 March ozone losses can only be forecasted~1 month in advance. Nevertheless, a good prediction of the stratospheric ozone shows little impact on the surface predictability in the Northern Hemisphere.