Brief Effect of Acupuncture on the Peripheral Arterial System of the Upper Limb and Systemic Hemodynamics in Humans

Takayama, Shin; Seki, Takashi; Watanabe, Masashi; Monma, Yuto; Yang, San Yue; Sugita, Norihiro; Konno, Satoshi; Saijo, Yoshifumi; Yambe, Tomoyuki; Yaegashi, Nobuo; Yoshizawa, Makoto; Nitta, Shin Ichi

doi:10.1089/acm.2009.0355

Cited by 26 publications

(34 citation statements)

References 29 publications

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“…Doppler ultrasound has been used clinically for noninvasive assessment of the SMA hemodynamics. We have already reported the changes of blood flow volume in the SMA and brachial artery due to abdominal thermal stimulation and the effect of acupuncture on radial artery blood flow volume by ultrasound [16][17][18]. These reports suggested the efficacy of ultrasound for assessing the blood flow change in the various organs treated by traditional medicine.…”

Section: Introductionmentioning

confidence: 93%

The Effect of Warming of the Abdomen and of Herbal Medicine on Superior Mesenteric Artery Blood Flow – a Pilot Study

Takayama

Seki

Watanabe

et al. 2010

Forsch Komplementmed

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Background: In traditional Japanese and Chinese medicine, warming the abdomen with moxibustion or herbal medicines has been used for various diseases. However, the effects of these therapies on hemodynamics have not been clear. We clarify the physiological effects of these therapies on the superior mesenteric artery (SMA) blood flow. Participants and Methods: 28 healthy male volunteers were randomly assigned to groups A and B. Group A (n = 14) underwent local thermal stimulation of the paraumbilical region for 20 min at a temperature of 40 °C; this simulated the heat and mechanical pressure effects of moxibustion. Group B (n = 14) took the herbal medicine Daikenchuto (TJ-100; 5.0 g) with distilled water. As a control, group C (n = 14) took distilled water alone. Blood flow volume in the SMA was measured by ultrasound from rest to 50 min after the start of each intervention. Results: The SMA blood flow volume increased significantly between 10 to 40 min after the start of thermal stimulation (p < 0.05), and it also increased significantly between 10 to 50 min after administration of TJ-100 (p < 0.01) as compared to the resting volume. However, SMA blood flow volume did not change significantly after administration of water alone. There was no significant difference in SMA blood flow changes between groups A and B. Conclusions: The results suggest that one of the physiological effects of warming the abdomen according to a traditional concept in thermal stimulation and herbal medicine is an increase of SMA blood flow volume.

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Section: Introductionmentioning

confidence: 93%

The Effect of Warming of the Abdomen and of Herbal Medicine on Superior Mesenteric Artery Blood Flow – a Pilot Study

Takayama

Seki

Watanabe

et al. 2010

Forsch Komplementmed

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“…Pulsed Doppler ultrasound has been used clinically for noninvasive assessment of SMA hemodynamics. We have already reported on blood flow volume changes in the SMA and brachial artery in response to abdominal thermal stimulation as well as changes in radial artery blood flow volume in response to acupuncture, as determined by ultrasound (Takayama 2009a(Takayama , 2009b(Takayama , 2009c. These reports suggest that ultrasound is effective for assessing the hemodynamic effects of traditional medicines.…”

mentioning

confidence: 90%

The Herbal Medicine Daikenchuto Increases Blood Flow in the Superior Mesenteric Artery

Takayama

Seki

Watanabe

et al. 2009

Tohoku J. Exp. Med.

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“…Therefore, scientific elucidation of underlying acupuncture mechanism is essential for the therapy to be generally accepted in the future. There are only few studies in which quantitative measurement of blood flow in response to stimulation of a specific acupoint was conducted at clinical sites11, 12, 13; whereas, numerous studies were conducted on hemodynamic change following acupuncture therapy. Takayama et al 11 measured blood pressure (BP), cardiac index (CI) and systemic vascular resistance index (SVRI), and the diameter and blood flow volume of left brachial and radial arteries in response to acupuncture therapy applied to Taichong (LR-3), focusing on the effect of the stimulation of the acupoint on the hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

“…There are only few studies in which quantitative measurement of blood flow in response to stimulation of a specific acupoint was conducted at clinical sites11, 12, 13; whereas, numerous studies were conducted on hemodynamic change following acupuncture therapy. Takayama et al 11 measured blood pressure (BP), cardiac index (CI) and systemic vascular resistance index (SVRI), and the diameter and blood flow volume of left brachial and radial arteries in response to acupuncture therapy applied to Taichong (LR-3), focusing on the effect of the stimulation of the acupoint on the hemodynamics. The authors of that study demonstrated that blood flow volume in the arm decreased during twisting of the acupuncture needle and then increased to a level higher than the preacupuncture level at 180 seconds after the stimulation, while BP and CI were not changed.…”

Section: Introductionmentioning

confidence: 99%

“…Vasoconstriction of digital blood vessels, unlike the case of other vessels, is regulated only by the sympathetic nervous system, 14 and change in peripheral blood circulation at the fingernail bed by acupuncture has been reported 15 . Therefore, Takayama et al 11 argued that the steep decrease and subsequent gradual increase in the blood flow volume were due to the change in peripheral vascular resistance induced by tension and sedation of the sympathetic nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Numerical reproduction of hemodynamics change by acupuncture on Taichong (LR-3) based on the lumped-parameter approximation model of the systemic arteries

Shirai¹,

Suzuki²,

Seki³

2015

Integrative Medicine Research

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BackgroundThe aim of this study was to develop a mathematical model of blood flow in the systemic circulation to emulate the change in hemodynamics by acupuncture therapy to elucidate the mechanism of the therapy. For this purpose, as a first step, a simple model of arterial blood flow was presented to reproduce previously reported change in the blood flow volume by the acupuncture needle stimulation of Taichong (LR-3).MethodsThis model was based on the lumped-parameter approximation of arterial blood flow together with linear resistance of peripheral circulation. It has been reported that blood flow in the left arm was enhanced after the stimulation, yielding the peripheral vascular resistance-regulated blood flow dominated by the sympathetic nervous system. In addition to the peripheral resistance, another parameter that possibly regulates the blood flow is the cross-sectional area of the vessel. These two factors were changed to numerically examine their contributions to the blood flow based on the hypothesis that they could be changed by the stimulation. The numerical result was compared with the experimental result to confirm the validity of the hypothesis that the blood flow in the arm is regulated by the peripheral resistance.ResultsThis model is extremely simple and the physical parameters introduced for the simulation were gleaned from different reports in the literature. It was demonstrated, however, that regulation of the peripheral resistance rather than of the cross-sectional area could reproduce the experimentally observed change in the blood flow. Moreover, the relationship between the changes in the flow volume and the systemic vascular resistance quantitatively matched the experimental data.ConclusionThe present model has a potential to emulate hemodynamic change by acupuncture therapy by incorporating physiological correlation of stimulation of an acupoint and regulation of parameters that affect the hemodynamics.

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Brief Effect of Acupuncture on the Peripheral Arterial System of the Upper Limb and Systemic Hemodynamics in Humans

Abstract: The present study showed that radial and brachial artery blood flow volume decreased immediately during acupuncture on LR-3 acupoint, but increased at 180 seconds after acupuncture. This reaction is attributed to the change in peripheral vascular resistance.

Cited by 26 publications

References 29 publications

The Effect of Warming of the Abdomen and of Herbal Medicine on Superior Mesenteric Artery Blood Flow – a Pilot Study

The Effect of Warming of the Abdomen and of Herbal Medicine on Superior Mesenteric Artery Blood Flow – a Pilot Study

The Herbal Medicine Daikenchuto Increases Blood Flow in the Superior Mesenteric Artery

Numerical reproduction of hemodynamics change by acupuncture on Taichong (LR-3) based on the lumped-parameter approximation model of the systemic arteries

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