2004
DOI: 10.1111/j.1460-9568.2004.03704.x
|View full text |Cite
|
Sign up to set email alerts
|

Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD‐1 mice

Abstract: The present study assessed alterations in mesolimbic enkephalin (ENK) mRNA levels after predator [2,5-dihydro-2,4,5-trimethylethiazoline (TMT)] and non-predator (butyric acid) odor encounter and/or light-dark (LD) testing in CD-1 mice immediately, 24, 48 and 168 h after the initial odor encounter and/or LD testing. The nucleus accumbens, ventral tegmental area, basolateral (BLA), central (CEA) and medial amygdaloid nuclei, prelimbic and infralimbic cortex were assessed for fos-related antigen (FRA) and/or ENK … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
72
1

Year Published

2005
2005
2018
2018

Publication Types

Select...
8
1

Relationship

3
6

Authors

Journals

citations
Cited by 98 publications
(77 citation statements)
references
References 89 publications
4
72
1
Order By: Relevance
“…Withdrawn mice were then kept in separate cages and perfused two hours after the injection. To avoid the possibility of novelty or stress-induced induction of c-Fos in NAc, opioid withdrawal signs were not explicitly scored in separate observation chambers in the present study (Hebb et al, 2004). Nonetheless, withdrawal signs appeared comparable to those reported previously (Hacker et al, 2006;Bagley et al, 2011).…”
Section: Drugs and Drug Administration Protocolsmentioning
confidence: 51%
“…Withdrawn mice were then kept in separate cages and perfused two hours after the injection. To avoid the possibility of novelty or stress-induced induction of c-Fos in NAc, opioid withdrawal signs were not explicitly scored in separate observation chambers in the present study (Hebb et al, 2004). Nonetheless, withdrawal signs appeared comparable to those reported previously (Hacker et al, 2006;Bagley et al, 2011).…”
Section: Drugs and Drug Administration Protocolsmentioning
confidence: 51%
“…Exposure to fox urine increases anxiety (Hebb et al, 2004) and disrupts memory function (Morrow et al, 2000) in rodents and therefore represents a likely model for a more threatening stressor than acute immobilization alone. It is also commonly used to model PTSD-like symptoms in rodents (Janitzky et al, 2015) and may therefore represent a good stimulus for rejection of social support.…”
Section: Predator Odor Stress Eliminates the Prosocial Effects Of Acumentioning
confidence: 99%
“…Since opioid systems in the amygdala modulate nociceptive responses (Kang et al, 1999), this test was modified from that described in Wilson et al (2004) by substituting a noxious (predator) odor rather than a shock probe. Predator odor can induce a similar burying behavior as that seen after shock probe exposure (see Hebb et al, 2004). A Plexiglas chamber (45 Â 30 Â 44 cm) filled up to a depth of 5 cm with fresh pine bedding, with a piece of ferret-scented towel (5 cm 2 ) placed 2 cm above bedding, was used for this analysis.…”
Section: Behavioral Testingmentioning
confidence: 99%
“…Large numbers of enkephalin-immunoreactive neurons are observed in the amygdala (Roberts, 1992;Veinante et al, 1997;Fallon and Leslie, 1986;Gray et al, 1984;Harlan et al, 1987), and the central nucleus of the amygdala (CEA) receives enkephalin afferents from the bed nucleus of the stria terminalis (BNST) as well as other amygdalar nuclei (Poulin et al, 2006). The number of enkephalin neurons and enkephalin mRNA expression show differences between high-anxiety and low-anxiety mice, enkephalin mRNA expression in the amygdala is altered by exposure to predator odor, and pre-proenkephalin-knockout mice show increased levels of anxiety-like behaviors (Konig et al, 1996;Hebb et al, 2004;Filliol et al, 2000). Enkephalins interact with both mu-opioid receptors (MORs) and delta-opioid receptors (DORs), both of which are seen in the amygdala (Mansour et al, 1993(Mansour et al, , 1994a(Mansour et al, , b, 1987(Mansour et al, , 1995Poulin et al, 2006;Wilson et al, 2002;Goodman et al, 1980) and could mediate the effects of amygdalar enkephalin in anxiety or fear responses.…”
Section: Introductionmentioning
confidence: 99%