Brief History of<scp>ICT</scp>Molecules

doi:10.1002/9783527801916.ch2

Intramolecular Charge Transfer 2018

DOI: 10.1002/9783527801916.ch2

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Brief History ofICTMolecules

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Cited by 11 publications

References 112 publications

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A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

Sarkar,

Shil,

Maity

et al. 2023

Angewandte Chemie

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Aryl alcohol‐type or phenolic fluorophores offer diverse opportunities for developing bioimaging agents and fluorescence probes. Due to the inherently acidic hydroxyl functionality, phenolic fluorophores provide pH‐dependent emission signals. Therefore, except for developing pH probes, the pH‐dependent nature of phenolic fluorophores should be considered in bioimaging applications but has been neglected. Here we show that a simple structural remedy converts conventional phenolic fluorophores into pH‐resistant derivatives, which also offer “medium‐resistant” emission properties. The structural modification involves a single‐step introduction of a hydrogen‐bonding acceptor such as morpholine nearby the phenolic hydroxyl group, which also leads to emission bathochromic shift, increased Stokes shift, enhanced photo‐stability and stronger emission for several dyes. The strategy greatly expands the current fluorophores’ repertoire for reliable bioimaging applications, as demonstrated here with ratiometric imaging of cells and tissues.

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A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

Sarkar,

Shil,

Maity

et al. 2023

Angewandte Chemie

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A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

Sarkar,

Shil,

Maity

et al. 2023

Angew Chem Int Ed

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Recent Advances in Thermally Activated Delayed Fluorescent Materials in Type II Photodynamic Therapy

Berbigier,

da Luz,

Rodembusch

2024

The Chemical Record

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Photodynamic therapy (PDT) represents a novel, dual‐stage cancer treatment approach that combines light energy and photosensitizers to destroy cancerous and precancerous cells through the generation of radicals (Type I) or singlet oxygen (Type II). Since the early 2010s, PDT has advanced significantly, with the focus shifting toward the exploration of molecules capable of thermally activated delayed fluorescence (TADF) as viable alternatives to traditional metallic complexes and organometallic compounds for producing the necessary active species. TADF molecules exhibit higher energy conversion efficiency, long‐lived triplet excitons, tunable photophysical properties, and a small singlet‐triplet energy gap, facilitating efficient intersystem crossing and enhanced singlet oxygen generation. As metal‐free luminophores, they offer benefits such as reduced health risks, high structural flexibility, and biocompatibility, which can significantly enhance PDT treatment efficacy. Notably, in 2019, a pivotal shift occurred, with researchers concentrating their efforts on identifying and investing in potential molecules specifically for Type II PDT applications. This review presents the innovative use of materials characterized by closely spaced S1 and T1 orbitals, crucial for the efficient generation of singlet oxygen in PDT. Exploring these materials opens new avenues for enhancing the efficacy and specificity of PDT, offering promising for future cancer treatments.

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Brief History ofICTMolecules

Cited by 11 publications

References 112 publications

A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

A General Strategy Toward pH‐Resistant Phenolic Fluorophores for High‐Fidelity Sensing and Bioimaging Applications

Recent Advances in Thermally Activated Delayed Fluorescent Materials in Type II Photodynamic Therapy

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