2023
DOI: 10.1186/s12903-023-03181-x
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Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

Abstract: Objective Periodontitis is a chronic oral disease prevalent worldwide, and natural products are recommended as adjunctive therapy due to their minor side effects. Curcumin, a widely used ancient compound, has been reported to possess therapeutic effects in periodontitis. However, the exact mechanism underlying its activity remains unclear. In this context, the present study aimed to conduct computational simulations to uncover the potential mechanism of action of Curcumin in the treatment of pe… Show more

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Cited by 3 publications
(2 citation statements)
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“…Curcumin also inhibits the expression of inducible nitric oxide synthase (iNOS) enzyme by inflammatory and epithelial cells, which may play a role in periodontal inflammation ( Nakatake et al, 2017 ; Wang et al, 2019 ). On the other hand, it has been reported Curcumin molecule bind to CXCL8 chemokine and inhibit ferroptosis in ligature-induced periodontal-diseased mice, thus, play a pivotal role in treatment of periodontitis ( Huang et al, 2023 ; Wang et al, 2023 ). Finally, Curcumin inhibits the JAK/STAT signaling pathway and phosphorylation of p38 MAPK, thus reducing the expression of iNOS, COX-2, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1 during inflammatory periodontal disease ( Nakatake et al, 2017 ; Wang et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Curcumin also inhibits the expression of inducible nitric oxide synthase (iNOS) enzyme by inflammatory and epithelial cells, which may play a role in periodontal inflammation ( Nakatake et al, 2017 ; Wang et al, 2019 ). On the other hand, it has been reported Curcumin molecule bind to CXCL8 chemokine and inhibit ferroptosis in ligature-induced periodontal-diseased mice, thus, play a pivotal role in treatment of periodontitis ( Huang et al, 2023 ; Wang et al, 2023 ). Finally, Curcumin inhibits the JAK/STAT signaling pathway and phosphorylation of p38 MAPK, thus reducing the expression of iNOS, COX-2, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1 during inflammatory periodontal disease ( Nakatake et al, 2017 ; Wang et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Machine learning offers significant advantages and impressive progress in identifying disease biomarkers (19)(20)(21)(22). While traditional biomarker research usually takes a lot of time and resources, machine learning methods can efficiently extract key features from large-scale biological data and accelerate the biomarker discovery process (23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%