Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study

Aran, Adi; Cassuto, Hanoch; Lubotzky, Asael; Wattad, Nadia; Hazan, Esther

doi:10.1007/s10803-018-3808-2

Cited by 146 publications

(186 citation statements)

References 16 publications

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“…These results are consistent with other preliminary reports of the effectiveness of cannabis in ASD. 4,5 Hence, based on the parents' reported outcomes, this study suggests that cannabidiol may be effective in improving ASD comorbidities symptoms, with few and transient adverse effects. However, the long-term effects and safety of these preparations should be evaluated in further large-scale, controlled studies.…”

Section: Medical Cannabidiol In Children With Autism Spectrum Disordermentioning

confidence: 79%

“…8 As shown above, recently, the use of cannabinoids has been described for symptoms related to ASD as well as for other disruptive behaviors, with apparent favorable effects. 4 We therefore performed a retrospective pilot study to analyze the effect of cannabis in children and young adults diagnosed with FASD according to internationally accepted criteria. 9 The study protocol was approved by the Shamir Hospital Research Ethics Committee, and informed consent was given by the parents for use of anonymous data.…”

Section: Use Of Cannabis In Fetal Alcohol Spectrum Disordermentioning

confidence: 99%

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Medicinal Use of Cannabis in Children and Pregnant Women

Koren

Cohen

2020

Rambam Maimonides Med J

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The increasing medicinal use of cannabis during recent years has largely overlooked children and pregnant women due to litigious and ethical concerns. However, over the last few years medicine has observed increasing numbers of children treated with cannabis for autism spectrum disorder (ASD) and fetal alcohol spectrum disorder (FASD), and pregnant women treated for hyperemesis gravidarum (HG). This review provides an account of major findings discovered through this research. Specifically, cannabis may offer therapeutic advantages to behavioral symptoms of autism spectrum disorder and fetal alcohol spectrum disorder, and to the severe nausea and vomiting in hyperemesis gravidarum. The use of medical cannabis in children and pregnant women should be further discussed and researched in this patient population.

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Section: Medical Cannabidiol In Children With Autism Spectrum Disordermentioning

confidence: 79%

Section: Use Of Cannabis In Fetal Alcohol Spectrum Disordermentioning

confidence: 99%

Medicinal Use of Cannabis in Children and Pregnant Women

Koren

Cohen

2020

Rambam Maimonides Med J

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“…The non-psychoactive, medical cannabis (e.g. cannabidiol, cannabidivarin) in ASD patients appears to be well tolerated, safe (a low side effects rate) and effective option to relieve autistic symptoms in some countries [30,31], nevertheless, the cannabinoid treatment remains a controversial ethical issue in individuals with ASD, and any kind of cannabinoid consumption is illegal in China. Collectively, eCBs, either as diagnostic biomarker or as potential therapeutic target, their decreased levels were associated with ASD.…”

Section: Discussionmentioning

confidence: 99%

The Alternations of Endocannabinoid System and its Therapeutic Potential in Autism Spectrum Disorder

Liu

Xie

Wang

et al. 2020

Preprint

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Background: Autism spectrum disorder (ASD) is a group of developmental disabilities whose etiology remains elusive. The endocannabinoid (eCB) system modulated neurotransmission and neuronal plasticity. Evidence points to the involvement of this neuromodulatory system in the pathophysiology of ASD. Herein we investigated if there was disruption of eCB system in ASD and if pharmacological modulators of eCB system might have a therapeutic potential. Methods: We examined three major components of eCB system, namely, endogenous cannabinoids, their receptors and associated enzymes, in ASD children as well as in VPA-induced ASD animal model. Meanwhile we specially increased 2-arachidonylglycerol (2-AG) by administering JZL184, a selective inhibitor of monoacylglycerol lipase, the hydrolytic enzyme for 2-AG, and to examine ASD-like behaviors in VPA-induced rats. Results: Autistic children and VPA-induced rats exhibited the reduced eCBs content, elevated degrading enzymes, and up-regulation of CBRs. We found that repetitive and stereotypical behaviors, hyperactivity, sociability, social preference, and cognitive functioning were improved after acute and chronic JZL184 treatment. The major efficacy of JZL184 was observed at the dose of 3mg/kg for both affecting eCB system and ASD-like behaviors. Conclusions: There were a lower eCB signaling in autistic children and ASD animal model, and boosting 2-AG could ameliorate ASD-like phenotypes in animals. Collectively, the results suggest a novel approach to ASD treatment.

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“…A preliminary study in Israel showed a decrease in disruptive behaviors and improved anxiety and communication problems in children with ASD. 41 A double-blind placebo-controlled crossover trial is ongoing. 42 What do we know about the safety and side effects of cannabis exposure in children?…”

Section: Drs Susanne W Duvall Phd Olivia Lindly Phd Mph Katharimentioning

confidence: 99%

Ethical Implications for Providers Regarding Cannabis Use in Children With Autism Spectrum Disorders

et al. 2019

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Children with autism spectrum disorder (ASD) are at risk for self-injurious behaviors that can be difficult to treat in the context of co-occurring low IQ and adaptive skills. Increased prevalence and decriminalization of cannabis in some states have led to more frequent questions for pediatricians about the use of cannabis for difficult-to-treat developmental and behavioral conditions. What do we know about the possible benefits and risks of cannabis use in children with ASD? How should the clinician respond to a parent who expresses interest in cannabis to manage behavior in a child with ASD? Ethical analysis that includes harm reduction, health concerns, and information sharing will be discussed. We present commentary on the ethical implications of cannabis use in children with ASD and severe self-harm behaviors.

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Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study

Cited by 146 publications

References 16 publications

Medicinal Use of Cannabis in Children and Pregnant Women

Medicinal Use of Cannabis in Children and Pregnant Women

The Alternations of Endocannabinoid System and its Therapeutic Potential in Autism Spectrum Disorder

Ethical Implications for Providers Regarding Cannabis Use in Children With Autism Spectrum Disorders

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