Brief report: Effects of fenfluramine on communicative, stereotypic, and inappropriate behaviors of autistic-type mentally handicapped individuals

Duker, Pieter C.; Welles, K; Seys, Daniel M.; Rensen, H; Vis, André N.; Berg, G van den

doi:10.1007/bf02207332

Cited by 16 publications

(2 citation statements)

References 17 publications

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“…Geller, Ritvo, Freeman, and Yuwiler (1982) reported an open study of three children in which improvement was shown on intellectual testing and in other areas. Others (Duker et al, 1991;Ekman, Miranda-Linne, Gillberg, Garle, & Wetterberg, 1989;Sherman, Factor, Swinson, & Darjes, 1989) similarly failed to show significant improvement over placebo. The initial reporting group noted continued positive responses (Ritvo, Freeman, Geller, & Yuwiler, 1983), but in a well-designed study, Campbell, Adams, Small, et al (1988) found no difference between fenfluramine and placebo either on rat-ings of stereotypy or on core symptoms of autism.…”

Section: Aspects Of Research Design and Methodsmentioning

confidence: 98%

Pharmacological Interventions in Autism: Theoretical and Practical Issues

Volkmar¹

2001

Journal of Clinical Child & Adolescent Psychology

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Focused on issues of drug treatment in relation to autism. Pharmacological treatment studies in autism are complicated by various factors including a tremendous range of syndrome expression, a lack of robust animal models of the disorder, and various methodological problems. Theories have tended to follow treatments, and various neurochemical systems have been the focus of study. Neurochemical systems potentially implicated include those involving dopamine, norepinephrine, serotonin, and neuropeptides. The dopaminergic system has been the most extensively studied. Treatments developed are effective relative to certain disabling symptoms but "core" problems (e.g., in social relatedness and communication) appear less responsive to medications. The development of new approaches to assessment, including integration of behavioral and pharmacological approaches, is an important research priority.

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Section: Aspects Of Research Design and Methodsmentioning

confidence: 98%

Pharmacological Interventions in Autism: Theoretical and Practical Issues

Volkmar¹

2001

Journal of Clinical Child & Adolescent Psychology

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“…Information on the outcome measures was insufficient and so this study did not merit inclusion. Duker et al (1991) This placebo-controlled study looked at the effects of fenfluramine on behaviour problems in 11 participants with ID. Behaviour recordings were made, which revealed a decrease in stereotypic and inappropriate behaviours.…”

Section: Included Studiesmentioning

confidence: 99%

The effectiveness of antidepressant medication in the management of behaviour problems in adults with intellectual disabilities: a systematic review

Sohanpal

Deb

Thomas

et al. 2007

J intellect Disabil Res

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Evidence based primarily on a small number of either prospective or retrospective case studies that included a small number of participants and often used non-validated outcome measures for a short period of follow-up, suggests that antidepressants, particularly SSRIs, show improvement of aggression and self-injurious behaviour on average in less than 50% of cases and the rest show either no improvement or deterioration. The effect is most pronounced in the presence of an underlying anxiety or an associated diagnosis of obsessive-compulsive disorder. Most studies have highlighted the concern regarding adverse effects.

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Effects of Tryptophan Depletion in Drug-Free Adults With Autistic Disorder

McDougle¹

1996

Arch Gen Psychiatry

276

180

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The results of this study are consistent with previous research that has implicated a dysregulation in serotonin function in some patients with autism. These data suggest that the short-term reduction of serotonin precursor availability may exacerbate some symptoms characteristic of autism in some patients. Continued investigation into the role of serotonin in the pathogenesis and treatment of autistic disorder is warranted.

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Brief report: Effects of fenfluramine on communicative, stereotypic, and inappropriate behaviors of autistic-type mentally handicapped individuals

Cited by 16 publications

References 17 publications

Pharmacological Interventions in Autism: Theoretical and Practical Issues

Pharmacological Interventions in Autism: Theoretical and Practical Issues

The effectiveness of antidepressant medication in the management of behaviour problems in adults with intellectual disabilities: a systematic review

Effects of Tryptophan Depletion in Drug-Free Adults With Autistic Disorder

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