Objective: This study examines whether resilience and mentalizing capacities affect the network constellation of various protective and risk factors among psychotherapists during the COVID-19 pandemic. Method: A multinational sample of N = 536 psychotherapists completed surveys regarding their mentalizing capacity, general resilience, and therapist-specific resilience, as well as several other protective and risk factors. Network models of the latter factors were constructed, and global as well as local moderation analyses were conducted to examine their connectivity patterns. Results: At a global level, general and therapist-specific resilience, but not mentalizing certainty, increased absolute levels of network connectivity. At the local level, the two types of resilience specifically moderated the connections among protective factors by rendering them more positive; whereas mentalizing capacity moderated the connections between protective and risk factors by rendering them more negative. Conclusion: These findings suggest that (therapist-specific) resilience might be characterized by reinforcing links among protective factors, whereas mentalizing might be typified by weakening effects of risk factors––patterns which could prove useful for enhancing psychotherapists’ wellbeing during times of global but also personal crises.