Bright light exposure induces dynamic changes of spatial memory in nocturnal rodents

Shang, Mengjuan; Zhang, Jimeng; Shen, Meilun; Sun, Zhi-Chuan; Gao, Peng; Li, Jing; Xing, Jun-Ling; Guo, Guozhen

doi:10.1016/j.brainresbull.2021.06.019

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…For example, rats subjected to bright light during 4 weeks experienced increased hippocampal BDNF expression [ 26 , 69 ], compared to the dim light [ 69 ] or control group [ 26 ], while, in turn, the exposure to dim light induced the decrease in hippocampal BDNF expression [ 69 ]. Similarly, bright light treatment in mice resulted in an increase in hippocampal mRNA BDNF expression and activated BDNF/TrkB signaling in comparison to dim light exposure [ 70 ]. A marginal correlation was found between the BDNF gene expression level in peripheral blood and the plasma level in the drug-naïve first-episode MDD group [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression

Kosanovic Rajacic,

Sagud,

Begic

et al. 2023

Biomolecules

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Brain-derived neurotrophic factor (BDNF) is implicated in the etiology and treatment response in major depressive disorder (MDD). However, peripheral BDNF concentrations have not been compared across different MDD stages. Bright light therapy (BLT) offers some potential in treatment-resistant depression (TRD), but its effects on BDNF levels are unknown. This study included a cross-sectional analysis of plasma BDNF concentration in females with TRD, unmedicated MDD patients, and healthy controls (HC), and measurements of longitudinal BLT effects on plasma BDNF levels in TRD patients. The present study included 55 drug-naïve, first-episode patients, 25 drug-free recurrent-episode MDD patients, 71 HC participants, and 54 TRD patients. Patients were rated by Hamilton Depression Rating Scale (HAMD)-17 and the Montgomery–Åsberg Depression Rating Scale (MADRS). Patients with TRD received BLT during 4 weeks. The total HAMD-17 and MADRS scores decreased following BLT. All patient groups had lower plasma BDNF than HC, but BDNF levels did not differ between first- and recurrent-episode BDNF patients and TRD patients before or after BLT. However, responders and remitters to BLT had higher post-treatment plasma BDNF concentrations than patients who did not achieve response or remission. The changes in plasma BDNF levels may be candidates for biomarkers of treatment response to BLT in TRD patients.

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Section: Discussionmentioning

confidence: 99%

Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression

Kosanovic Rajacic,

Sagud,

Begic

et al. 2023

Biomolecules

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“…The paradigms established in this study are highly practical, efficient, and convenient, mainly reflected in the following aspects. (1) Paradigms for human beings are required to discriminate similar images via visual inputs, and by the same token (Riphagen et al, 2020;Li et al, 2021), we imitate them to develop paradigms for mice by displaying similar images on the touchscreen. (2) Bowen et al (2020) and Miendlarzewska et al (2016) believed that food restriction could promote task motivation.…”

Section: Discussionmentioning

confidence: 99%

“…Stress may affect motivation in some behavioral tests, and the disturbed motivation may further confuse behavior analysis. For example, bright light is a stressor for rodents; mice maintained in brighter light exhibited spatial memory impairment in the Y maze ( Shang et al, 2021 ); and light-intensity-dependent disruptive effects on the object and odor recognition memory task were also reported ( Hasan et al, 2021 ). Contextual fear discrimination ( Kheirbek et al, 2012 ) and its adapted versions are typically negative paradigms.…”

Section: Introductionmentioning

confidence: 99%

A touchscreen-based paradigm to measure visual pattern separation and pattern completion in mice

Wang¹,

Sun²,

Wang³

et al. 2022

Front. Neurosci.

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Memory accuracy involves two major processes: pattern separation and pattern completion. Pattern separation refers to the ability to reduce overlap among similar inputs to avoid interference, and pattern completion refers to the ability to retrieve the whole information from partial or degraded cues. Impairments in pattern separation/pattern completion contribute to cognitive deficits in several diseases of the nervous system. Therefore, it is better to evaluate both pattern separation and pattern completion in one apparatus. However, few tools are available to assess pattern separation and pattern completion within the same apparatus for rodents. In this study, we designed a series of images with varying degrees of similarity to the correct image to evaluate pattern separation and pattern completion. First, mice were trained to discriminate between two totally different images, and once the correct percentage reached above 77% for two consecutive days, the images with different degrees of similarity were used to measure pattern separation and pattern completion. The results showed the mice performed progressively worse from S0 to S4 (increasing similarity) when discriminating similar images in pattern separation, and the mice performed progressively worse from C0 to C4 (decreasing cues information) when recalling the correct image according to partial cues in pattern completion, implying a good image similarity-dependent manner for memory accuracy evaluation. In sum, we designed a convenient, effective paradigm to evaluate pattern separation and pattern completion based on a touchscreen pairwise discrimination task, which may provide a new method for the studies of the effects and mechanisms of memory accuracy enhancing drugs.

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“…It has been found that the cognition promoting effects of LT associated with upregulated BDNF levels. These effects have been documented in humans [28,29] , as well as in laboratory animals [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Light treatment ameliorates sub-chronic MK-801-induced cognitive deficits in mice through up-regulating BDNF/p-CREB/p-ERK signaling pathway

Cui

Zhou

Zhang

et al. 2023

Preprint

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Cognitive impairment associated with schizophrenia (CIAS) is regarded as a core symptom of the illness, and there is still no effective treatment. Light plays an important role in regulation of cognitive functions. However, whether light treatment (LT) can improve CIAS remains unknown. The current study investigated the efficacy of LT on CIAS and explored the underlying molecular mechanisms in a CIAS model. The CIAS and control group were sub-chronically injected with MK-801 and saline respectively, and the LT/CIAS group were CIAS mice exposed to LT (3,000 Lux, 2 hr/day, 3 weeks). Results showed that the performance of LT/CIAS mice significantly improved in the novel object recognition test, novel location recognition test and Morris water maze compared with the CIAS group. And the behavioral improvement effects of LT could last over 4 weeks after LT was terminated. Golgi-cox staining revealed that the dendritic spine density and morphological complexity of hippocampal CA1 pyramidal neurons were increased after 3 weeks LT. Further research found that higher expression of brain-derived neurotrophic factor (BDNF), accompanied by elevated cAMP response element-binding phosphorylation (p-CREB) level in the hippocampus of LT/CIAS group compared to the CIAS group. Moreover, LT elevated phosphorylated extracellular signal-regulated kinase (p-ERK) level in the hippocampus of LT/CIAS group compared to the CIAS group. Taken together, long term LT ameliorated sub-chronic MK-801-induced cognitive deficits in mice, and the altered dendritic spines density and morphology of CA1 pyramidal neurons were rescued in LT/CIAS mice group, which might associate with up-regulating BDNF/p-CREB/p-ERK signaling pathway in LT/CIAS mice.

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Bright light exposure induces dynamic changes of spatial memory in nocturnal rodents

Cited by 6 publications

References 49 publications

Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression

Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression

A touchscreen-based paradigm to measure visual pattern separation and pattern completion in mice

Light treatment ameliorates sub-chronic MK-801-induced cognitive deficits in mice through up-regulating BDNF/p-CREB/p-ERK signaling pathway

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