Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study

Haffmans, P.M.J.; Sival, Rob C.; Lucius, Stefan; Cats, Quirine; Gelder, Lies van

doi:10.1002/1099-1166(200101)16:1<106::aid-gps288>3.0.co;2-9

Cited by 87 publications

(56 citation statements)

References 15 publications

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“…brain) to promote aggressive behaviour [7]. In accordance with these findings, exogenous melatonin administered to human clinical populations is associated with increased aggression [44,45].…”

Section: Discussionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for limited resources, the mechanisms underlying female aggression remain understudied. Here, we propose a previously undescribed endocrine mechanism regulating female aggression via direct action of the pineal hormone melatonin on adrenal androgens. We examined this in a solitary hamster species, Phodopus sungorus, in which both sexes are highly territorial across the seasons, and display increased aggression concomitant with decreased serum levels of sex steroids in short 'winter-like' days. Short-but not long-day females had increased adrenal DHEA responsiveness co-occurring with morphological changes in the adrenal gland. Further, serum DHEA and total adrenal DHEA content were elevated in short days. Lastly, melatonin increased DHEA and aggression and stimulated DHEA release from cultured adrenals. Collectively, these findings demonstrate that DHEA is a key peripheral regulator of aggression and that melatonin coordinates a 'seasonal switch' from gonadal to adrenal regulation of aggression by direct action on the adrenal glands.

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Section: Discussionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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“…Three recent controlled trials have been published with some evidence for improving restlessness and with particular benefit for sleep disturbances (e.g. see Haffmanns et al, 2001).…”

Section: Other Therapiesmentioning

confidence: 99%

Non-pharmacological interventions in dementia

Douglas¹,

James²,

Ballard³

2004

Adv. psychiatr. treat

234

172

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It is increasingly recognised that pharmacological treatments for dementia should be used as a second-line approach and that non-pharmacological options should, in best practice, be pursued first. This review examines current non-pharmacological approaches. It highlights the more traditional treatments such as behavioural therapy, reality orientation and validation therapy, and also examines the potential of interesting new alternative options such as cognitive therapy, aromatherapy and multisensory therapies. The current literature is explored with particular reference to recent research, especially randomised controlled trials in the area. Although many non-pharmacological treatments have reported benefits in multiple research studies, there is a need for further reliable and valid data before the efficacy of these approaches is more widely recognised.

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“…Dowling, Graf, Hubbard, and Luxenberg (2007) Skjerve et al (2004) (n = 10), and Haffmans, Sival, Lucius, Cats, and Van Gelder (2001) (n = 6) investigated the effect of bright light exposure on older adults with dementia and found a significant improvement in agitation. Barrick et al (2010) (n = 66) and Lyketsos, Veiel, Baker, and Steele (1999) (n = 15) evaluated bright light exposure in older adults with dementia and found no significant improvement in agitation.…”

mentioning

confidence: 99%

Effect of Bright Light Exposure on Depression and Agitation in Older Adults with Dementia

Onega

Pierce

Epperly³

2016

Issues in Mental Health Nursing

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This study examined the effects of bright light exposure on three measures of depression and four measures of agitation in persons with dementia residing in long-term care. Using a randomized controlled design, participants were randomly assigned to receive either bright light (n = 30) or low intensity light (n = 30) for eight weeks. Bright light exposure was associated with significant improvement in depression and agitation, while participants receiving low intensity light displayed higher levels of depression and agitation or no significant change. Findings support the use of bright light exposure to reduce depression and agitation in this population.

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Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study

Cited by 87 publications

References 15 publications

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

Non-pharmacological interventions in dementia

Effect of Bright Light Exposure on Depression and Agitation in Older Adults with Dementia

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