Bright Light Therapy: Improved Sensitivity to Its Effects on Rest-Activity Rhythms in Alzheimer Patients by Application of Nonparametric Methods

Someren, Eus J.W. Van; Swaab, D.F.; Colenda, Christopher C.; Cohen, Wayne R.; McCall, W. Vaughn; Rosenquist, Peter B.

doi:10.3109/07420529908998724

Cited by 522 publications

(459 citation statements)

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“…However, phase advancing was paused by a phase delay in a point between the 6-month-old babies and young adults that presumably could occur during the adolescence (Roenneberg et al 2007). Regarding the enhancing of the first harmonic, it was consistently increased in all the groups with the exception of older people, probably due to the disruption of the CS by rhythm fragmentation as described for sleep and activity (Van Someren et al 1999).…”

Section: Discussionmentioning

confidence: 84%

“…Because the wrist temperature (WT) rhythm has a shape that is far from sinusoidal in many subjects, a nonparametric analysis was performed as described by Van Someren et al (1999). This analysis permits the calculation of interdaily stability (IS, the consistency of the 24-h rhythmic pattern over days), intradaily variability (IV, the rhythm fragmentation), the hourly average during 2 consecutive hours, along with the minimum temperature (L2) and its timing (TL2), the hourly average during 5 consecutive hours, along with the maximum temperature (M5) and its timing (TM5), the hourly average during 10 consecutive hours, along with the minimum temperature (L10) and its respective timing (TL10), and the relative amplitude (RA) determined as the difference between M5 and L10, divided by the sum of M5 and L10, and the circadian function index or CFI, as previously described .…”

Section: Discussionmentioning

confidence: 99%

“…During the adulthood, CS is mature, but gender differences appear during this period related to chronotype (Adan and Natale 2002). Finally, aging is associated with a phase advance, fragmentation, and flattening of marker rhythms (robust, easy-to-register, noninvasive, and comfortable circadian rhythm driven by the circadian pacemaker) (Hofman and Swaab 2006;Van Someren et al 1999).…”

Section: Introductionmentioning

confidence: 99%

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Ontogeny and aging of the distal skin temperature rhythm in humans

Batinga

Martínez-Nicolás

Zornoza-Moreno

et al. 2015

AGE

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In circadian terms, human ontogeny is characterized by the emergence of a daily pattern, from a previous ultradian pattern, for most variables during the first 6 months of life. Circadian aging in humans is characterized by a phase advance, accompanied by rhythm fragmentation and flattening. Despite an expanding body of literature focused on distal skin temperature, little information is available about the ontogeny and practically nothing about age-related changes in this rhythm. Thus, the aim was to evaluate the degree of maturation and aging of the circadian pattern of distal skin temperature to identify those parameters that are modified throughout life and could be used to differentiate subjects according to their age. For this, distal skin temperature was measured in 197 volunteers (55 % women), including babies aged 15 days (30 subjects), 1 month (28 subjects), 3 months (31 subjects), and 6 months (10 subjects); young adults aged 19 years (37 subjects); middle-aged persons aged 46 years (27 subjects); older people aged 72 (34 subjects). Circadian system maturation was associated with an increase in amplitude and a reduction in skin temperature during sleep. During adulthood, women showed a more robust pattern (lower fragmentation, and higher night-time temperature, amplitude, circadian function index, and first harmonic relative power); however, these differences were lost with aging, a period of life that was consistently associated with a phase advance of the rhythm. In summary, distal skin temperature pattern can be used as a robust variable to discern between different ages throughout the life.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ontogeny and aging of the distal skin temperature rhythm in humans

Batinga

Martínez-Nicolás

Zornoza-Moreno

et al. 2015

AGE

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“…Actograms were performed using the Clocklab software (Actimetrics Inc., Evanston, IL). Quantitative characteristics of the locomotor activity rhythm were determined with non-parametric methods as previously described (Van Someren et al, 1999;Huang et al, 2002). Briefly, the following variables were calculated from the locomotor activity data.…”

Section: Discussionmentioning

confidence: 99%

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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To cite this version:Fabienne Aujard, Florence Cayetanot, Jérémy Terrien, Eus J.W. Van Someren. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Experimental Gerontology, Elsevier, 2007, 42 (11) ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ABSTRACTAdaptation of physiological and behavioral functions to seasonal changes in daylength is of major relevance for optimal fitness and survival. Because aging is characterized by changes in biological rhythms, it may be hypothesized that old animals fall short of showing a full adaptation to prolonged changes in the duration of daily light exposure, as naturally occurring in relation to season in younger individuals. To test this hypothesis, we analyzed changes in the patterns of daily locomotor activity and body temperature rhythms of young and old mouse lemurs (Microcebus murinus, Primates) exposed to short and long daylengths. The effect of an increase in the duration of daily light exposure was attenuated in old animals, as compared to younger lemurs. Although some age-related differences in the locomotor activity rhythm could be seen under exposure to short daylength, they were predominant under long daylength. Some mechanisms allowing adaptation to changing day length thus seem to be impaired at old age. Changes in coupling of circadian oscillators to the light-dark cycle and disturbances in the physiological responses to change in light duration should be further investigated.

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“…Eleven activity variables were created for each person using parametric cosinor analysis [52; 53] and non-parametric circadian rhythm analysis (NPCRA) [54]. Cosinor analysis provided values for amplitude, mesor and acrophase (peak time) of the rest-activity rhythm.…”

Section: Study Protocolmentioning

confidence: 99%

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Hopkins

Morgan

Schlangen

et al. 2017

CAR

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Environmental (little outdoor light; low indoor lighting) and age-related physiological factors (reduced light transmission through the ocular lens, reduced mobility) contribute to a light-deprived environment for older people living in care homes. This study investigates the effect of increasing indoor light levels with blueenriched white lighting on objective (rest-activity rhythms, performance) and self-reported (mood, sleep, alertness) measures in older people. Eighty residents (69 female), aged 86 ± 8 yrs (mean ± SD), participated (MMSE 19 ± 6). Overhead fluorescent lighting was installed in communal rooms (n=20) of seven care homes.Four weeks of blue-enriched white lighting (17000 K  900 lux) were compared with four weeks of control white lighting (4000 K  200 lux), separated by three weeks wash-out. Participants completed validated mood and sleep questionnaires, psychomotor vigilance task (PVT) and wore activity and light monitors (AWL). Restactivity rhythms were assessed by cosinor, non-parametric circadian rhythm (NPCRA) and actigraphic sleep analysis. Blue-enriched (17000 K) light increased wake time and activity during sleep decreasing actual sleep time, sleep percentage and sleep efficiency (p < 0.05) (actigraphic sleep). Compared to 4000 K lighting, blueenriched 17000 K lighting significantly (p < 0.05) advanced the timing of participants' rest-activity rhythm (cosinor), increased daytime and night-time activity (NPCRA), reduced subjective anxiety (HADA) and sleep quality (PSQI). There was no difference between the two light conditions in daytime alertness and performance (PVT). Blue-enriched lighting produced some positive (increased daytime activity, reduced anxiety) and negative (increased night-time activity, reduced sleep efficiency and quality) effects in older people.Keywords: care home, light therapy; mood; elderly; rest-activity; sleep. 3 Graphical AbstractThe effect of blue-enriched 17000 K lighting (right) on the rest-activity, sleep and mood of older people living in care homes has been investigated compared to control 4000 K lighting (middle) (left, original lighting) 4

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Bright Light Therapy: Improved Sensitivity to Its Effects on Rest-Activity Rhythms in Alzheimer Patients by Application of Nonparametric Methods

Cited by 522 publications

References 44 publications

Ontogeny and aging of the distal skin temperature rhythm in humans

Ontogeny and aging of the distal skin temperature rhythm in humans

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

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