Bright light therapy improves cancer-related fatigue in cancer survivors: a randomized controlled trial

Johnson, Jillian A.; Garland, Sheila N.; Carlson, Linda E.; Savard, Josée; Simpson, Jennifer S.; Ancoli‐Israel, Sonia; Campbell, Tavis S.

doi:10.1007/s11764-017-0659-3

Cited by 74 publications

(72 citation statements)

References 30 publications

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“…For example, anti‐cytokine therapies may be beneficial for patients with elevated inflammation, although concerns about adverse effects limit the use of these agents in patients with cancer. Pharmacologic agents also could be used to target neurotransmitter, neuro‐immune, and other systems related to fatigue (eg, buproprion, minocycline), whereas bright‐light therapy could target circadian rhythm disturbance . Of note, given the multidimensional nature of fatigue, interventions that influence multiple systems may be most effective.…”

Section: Summary and Implications For Interventionmentioning

confidence: 99%

“…Pharmacologic agents also could be used to target neurotransmitter, neuro-immune, and other systems related to fatigue (eg, buproprion, minocycline), whereas bright-light therapy could target circadian rhythm disturbance. 124 Of note, given the multidimensional nature of fatigue, interventions that influence multiple systems may be most effective. Indeed, psychosocial, exercise, and mind-body interventions appear to be more beneficial for CRF than pharmacotherapy, 82 perhaps because these approaches have effects on a range of biobehavioral processes relevant for fatigue.…”

Section: Summary and Implications For Interventionmentioning

confidence: 99%

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The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms

Bower

2019

Cancer

144

120

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Fatigue is a common and distressing symptom in both patients with cancer and cancer survivors. There is substantial variation in the severity and persistence of cancer‐related fatigue that may be driven by individual differences in host factors, including characteristics that predate the cancer experience as well as responses to cancer and its treatment. This review examines biobehavioral risk factors linked to fatigue and the mechanisms through which they influence fatigue across the cancer continuum, with a focus on neuro‐immune processes. Among psychosocial risk factors, childhood adversity is a strong and consistent predictor of cancer‐related fatigue; other risk factors include history of depression, catastrophizing, lack of physical activity, and sleep disturbance, with compelling preliminary evidence for loneliness and trait anxiety. Among biologic systems, initial work suggests that alterations in immune, neuroendocrine, and neural processes are associated with fatigue. The identification of key risk factors and underlying mechanisms is critical for the development and deployment of targeted interventions to reduce the burden of fatigue in the growing population of cancer survivors. Given the multidimensional nature of fatigue, interventions that influence multiple systems may be most effective.

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Section: Summary and Implications For Interventionmentioning

confidence: 99%

Section: Summary and Implications For Interventionmentioning

confidence: 99%

The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms

Bower

2019

Cancer

144

120

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“…Studies specifically intervening on circadian rhythms that take into account the 24-h activity rhythm remain scarce. A number of studies have reported reduced circadian disruption after bright light therapy in patients with dementia [80], Parkinson's disease [81], depression [82], cardiovascular disease [83], and cancer [84]. However, it is largely unknown to what extent intervening on circadian factors and, subsequently 24-h activity rhythms, improves relevant clinical outcomes such as disease progression or mortality.…”

Section: Research Agendamentioning

confidence: 99%

24-h Activity Rhythms and Health in Older Adults

Feijter

Lysen

Luik

2020

Curr Sleep Medicine Rep

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Purpose of Review Circadian rhythms, including 24-h activity rhythms, change with age. Disturbances in these 24-h activity rhythms at older age have also been implied in various diseases. This review evaluates recent findings on 24-h activity rhythms and disease in older adults. Recent Findings Growing evidence supports that 24-h activity rhythm disturbances at older age are related to the presence and/or progression of disease. Longitudinal and genetic work even suggests a potential causal contribution of disturbed 24-h activity rhythms to disease development. Interventional studies targeting circadian and 24-h activity rhythms demonstrate that 24-h rhythmicity can be improved, but the effect of improving 24-h rhythmicity on disease risk or progression remains to be shown. Summary Increasing evidence suggests that 24-h activity rhythms are involved in age-related diseases. Further studies are needed to assess causality, underlying mechanisms, and the effects of treating disturbed 24-h activity rhythms on age-related disease.

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“…Early morning bright light therapy has been shown to protect against this disruption, which may also serve to protect against cancer‐related fatigue (Ancoli‐Israel et al., ; Neikrug et al., ). These findings have been replicated in patients with other types of cancer besides breast cancer (Johnson et al., ; Wu et al., ).…”

Section: Chronotherapymentioning

confidence: 75%

Circadian disruption and human health: A bidirectional relationship

Abbott

Malkani

Zee

2019

Eur J of Neuroscience

113

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Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.

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Bright light therapy improves cancer-related fatigue in cancer survivors: a randomized controlled trial

Abstract: These findings, along with previous reports of light therapy for CRF, support the use of this intervention to improve fatigue in cancer survivors.

Cited by 74 publications

References 30 publications

The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms

The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms

24-h Activity Rhythms and Health in Older Adults

Circadian disruption and human health: A bidirectional relationship

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