2011
DOI: 10.1159/000328950
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Bright-Light Therapy in the Treatment of Mood Disorders

Abstract: Bright-light therapy (BLT) is established as the treatment of choice for seasonal affective disorder/winter type (SAD). In the last two decades, the use of BLT has expanded beyond SAD: there is evidence for efficacy in chronic depression, antepartum depression, premenstrual depression, bipolar depression and disturbances of the sleep-wake cycle. Data on the usefulness of BLT in non-seasonal depression are promising; however, further systematic studies are still warranted. In this review, the authors present a … Show more

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Cited by 226 publications
(182 citation statements)
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“…Disrupted activity cycles are an important cause of mood relapses in BD [7]. Therapies for depression have been developed that directly target the circadian clock, including light exposure, melatonergic drugs, and shifting of sleep/wake schedules [88][89][90][91][92]. Candidate gene studies have identified a number of clock gene variants associated with MDD or BD, including BMAL1 (ARNTL1), CLOCK, NPAS2, PER3, CRY1, RORA and TIMELESS [93][94][95], but only RORA has been supported in more powerful GWAS [55,54,56].…”
Section: Major Depressive Disorder (Mdd) and Bipolar Disorder (Bd)mentioning
confidence: 99%
“…Disrupted activity cycles are an important cause of mood relapses in BD [7]. Therapies for depression have been developed that directly target the circadian clock, including light exposure, melatonergic drugs, and shifting of sleep/wake schedules [88][89][90][91][92]. Candidate gene studies have identified a number of clock gene variants associated with MDD or BD, including BMAL1 (ARNTL1), CLOCK, NPAS2, PER3, CRY1, RORA and TIMELESS [93][94][95], but only RORA has been supported in more powerful GWAS [55,54,56].…”
Section: Major Depressive Disorder (Mdd) and Bipolar Disorder (Bd)mentioning
confidence: 99%
“…7 The standard protocol is 10,000 lux (light intensity) for 30 minutes per day during the early morning for up to 6 weeks, with response usually seen within 1 to 3 weeks. 16,17 Proposed mechanisms of antidepressant action include the alteration of circadian rhythms 7 and modulation of serotonin and catecholamine systems. 18 Light therapy is generally well tolerated, 17 with common side effects being eye strain, headache, agitation, nausea, and sedation.…”
Section: What Is Light Therapy? How Effective Is Light Therapy For Thmentioning
confidence: 99%
“…16,17 Proposed mechanisms of antidepressant action include the alteration of circadian rhythms 7 and modulation of serotonin and catecholamine systems. 18 Light therapy is generally well tolerated, 17 with common side effects being eye strain, headache, agitation, nausea, and sedation. 19 Since 2009, 2 meta-analyses, 16,20 4 systematic reviews 17,19,21,22 and 3 RCTs [23][24][25] have been generally confirmatory of recommendations in the 2009 guidelines (see Suppl.…”
Section: What Is Light Therapy? How Effective Is Light Therapy For Thmentioning
confidence: 99%
“…For example, light treatment is highly effective as a treatment for seasonal affective disorder (SAD) (Pail et al, 2011) and according to the multidisciplinary guidelines mentioned above it is the treatment of first choice. A meta analysis by an APA work group shows that the effects of light treatment in SAD are comparable to the effects of treatment of non-seasonal depressions with antidepressants (Golden et al, 2005).…”
Section: Depressionmentioning
confidence: 99%