Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons

Chen, X.; Hu, Jiannan; Jiang, Liting; Xu, Shujun; Zheng, Bangxu; Wang, C; Zhang, J; Wei, Xiaofei; Chang, Lan; Wang, Q

doi:10.1016/j.neuroscience.2014.08.036

Cited by 84 publications

(58 citation statements)

References 32 publications

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“…Moreover, increased amyloid levels in mouse models of Alzheimer's disease results in decreased LTP and increased LTD (Palop and Mucke, 2010). In the mouse, infusion of beta amyloid into the hippocampus results in memory impairment, and when cultured neurons are treated with soluble beta amyloid, there are decreases in dendritic filopodia (Chen et al, 2014). …”

Section: Memory and Dendritic Spinesmentioning

confidence: 99%

The evolving role of dendritic spines and memory: Interaction(s) with estradiol

Frankfurt

Luine

2015

Hormones and Behavior

126

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Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the lifespan in female rodents. The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's Disease. It also addresses the role of acute and chronic estrogen treatment in these processes.

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Section: Memory and Dendritic Spinesmentioning

confidence: 99%

The evolving role of dendritic spines and memory: Interaction(s) with estradiol

Frankfurt

Luine

2015

Hormones and Behavior

126

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“…In addition, the brain of infected mice had a diminished number of PrPres after the administration of BBG in vivo [73]. It is noteworthy that recently BBG was shown to prevent neuronal loss in mouse models and modulates amyloid- β aggregation and cytotoxicity in cell-based assays, suggesting a new therapy for AD [74, 75]. …”

Section: Brilliant Blue Dyes In Vivo Assaysmentioning

confidence: 99%

Brilliant Blue Dyes in Daily Food: How Could Purinergic System Be Affected?

Ferreira

Faria

Ferreira

et al. 2016

International Journal of Food Science

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Dyes were first obtained from the extraction of plant sources in the Neolithic period to produce dyed clothes. At the beginning of the 19th century, synthetic dyes were produced to color clothes on a large scale. Other applications for synthetic dyes include the pharmaceutical and food industries, which are important interference factors in our lives and health. Herein, we analyzed the possible implications of some dyes that are already described as antagonists of purinergic receptors, including special Brilliant Blue G and its derivative FD&C Blue No. 1. Purinergic receptor family is widely expressed in the body and is critical to relate to much cellular homeostasis maintenance as well as inflammation and cell death. In this review, we discuss previous studies and show purinergic signaling as an important issue to be aware of in food additives development and their correlations with the physiological functions.

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“…Such concepts, if put within the adequate context, would surely strengthen our knowledge about neuroscience and provide fruitful details to understand neurological functioning, develop therapies (based on both biochemistry and pharmacology [11][12][13]), build animal models of neurological disease [14,15] such as Alzheimer's disease [16,18] and Parkinson disease [19].…”

Section: Editorialmentioning

confidence: 99%

“…Importantly, biochemistry also describes metabotropic receptors of the nervous system, such as the G protein coupled receptors [8], that play important roles in both neurophysiology [9] and neuropharmacology [10]. Furthermore, biochemistry governs biological events related to field such as genetic (gene expression) and proteomics that are closely related to the well-functioning of the nervous system as well.Such concepts, if put within the adequate context, would surely strengthen our knowledge about neuroscience and provide fruitful details to understand neurological functioning, develop therapies (based on both biochemistry and pharmacology [11][12][13]), build animal models of neurological disease [14,15] such as Alzheimer's disease [16,18] and Parkinson disease [19]. …”

mentioning

confidence: 99%

Towards More Implications of Biochemistry in Neuroscience

Ghanemi

2015

JNSK

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Editorialzymes, biomolecules, and ions. These elements play important role in the physiology and the biology of the nervous system and the neurons; including energy transfer, neurotransmitters synthesis and degradation, cell death and membranes potential. In addition biochemistry can explain the effects chemical can have on neurons too [7]. Importantly, biochemistry also describes metabotropic receptors of the nervous system, such as the G protein coupled receptors [8], that play important roles in both neurophysiology [9] and neuropharmacology [10]. Furthermore, biochemistry governs biological events related to field such as genetic (gene expression) and proteomics that are closely related to the well-functioning of the nervous system as well.Such concepts, if put within the adequate context, would surely strengthen our knowledge about neuroscience and provide fruitful details to understand neurological functioning, develop therapies (based on both biochemistry and pharmacology [11][12][13]), build animal models of neurological disease [14,15] such as Alzheimer's disease [16,18] and Parkinson disease [19].

show abstract

Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons

Cited by 84 publications

References 32 publications

The evolving role of dendritic spines and memory: Interaction(s) with estradiol

The evolving role of dendritic spines and memory: Interaction(s) with estradiol

Brilliant Blue Dyes in Daily Food: How Could Purinergic System Be Affected?

Towards More Implications of Biochemistry in Neuroscience

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