Brillouin Light Scattering: Applications in Biomedical Sciences

Palombo, Francesca; Fioretto, D.

doi:10.1021/acs.chemrev.9b00019

Cited by 129 publications

(126 citation statements)

References 112 publications

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“…Thus, unlike AFM, the effective length scales for which mechanical properties are measured depends on the characteristic scales of the acoustic waves being probed as well as the excitation-detection point spread function (scattering volume) which is defined by the effective numerical aperture of the objective lens. While the characteristic length scales of the derived mechanical properties are the former (namely the acoustic wavelength and attenuation length of the phonons), depending on the relative dimensions of the latter one may measure a spatial and orientational average in the probed volume [44,45].…”

Section: Brillouin Light Scatteringmentioning

confidence: 99%

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products

Andriotis¹,

Elsayad²,

Smart³

et al. 2019

Biomed. Opt. Express

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Accumulation of advanced glycation end-products (AGEs) in biological tissues occurs as a consequence of normal ageing and pathology. Most biological tissues are composed of considerable amounts of collagen, with collagen fibrils being the most abundant form. Collagen fibrils are the smallest discernible structural elements of load-bearing tissues and as such, they are of high biomechanical importance. The low turnover of collagen cause AGEs to accumulate within the collagen fibrils with normal ageing as well as in pathologies. We hypothesized that collagen fibrils bearing AGEs have altered hydration and mechanical properties. To this end, we employed atomic force and Brillouin light scattering microscopy to measure the extent of hydration as well as the transverse elastic properties of collagen fibrils treated with ribose. We find that hydration is different in collagen fibrils bearing AGEs and this is directly related to their mechanical properties. Collagen fibrils treated with ribose showed increased hydration levels and decreased transverse stiffness compared to controlled samples. Our results show that BLS and AFM yield complementary evidence on the effect of hydration on the nanomechanical properties of collagen fibrils.

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Section: Brillouin Light Scatteringmentioning

confidence: 99%

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products

Andriotis¹,

Elsayad²,

Smart³

et al. 2019

Biomed. Opt. Express

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“…Brillouin spectroscopy, or Brillouin elastography, is a spectroscopic technique capable of probing the mechanical properties of the sample by measuring its highfrequency viscoelastic modulus. This technique has been used to characterize local mechanical properties of a wide range of materials, including biological tissues [18][19][20]. A small in magnitude, 1 to 10 GHz, frequency shift of Brillouin-scattered photon occurs due to its interaction with the spontaneous thermally-excited phonons within the sample.…”

Section: Introductionmentioning

confidence: 99%

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Troyanova‐Wood

Gobbell

Meng

et al. 2020

Journal of Biophotonics

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Antihistamines, which are commonly used to treat allergic reactions, are known for their side effects, which contribute to weight gain. It is hypothesized that simultaneous Brillouin elastography and Raman spectroscopy can be used to detect changes in adipose tissue associated with a prolonged intake of desloratadine, a commonly used second generation antihistamine. White and brown adipose tissue samples were excised from adult rats following 16 weeks of daily administration of desloratadine. It was found that the prolonged intake of desloratadine leads to an increase in Brillouin shift in both adipose tissue types. Raman spectra indicate that antihistamine use reduces protein-to-lipid ratio in brown adipose tissue but not white adipose tissue, indicating the effect on adipose tissue is location-dependent.

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“…In this application, the combination of phonon-laser-induced mechanical line narrowing [36] with operation as a precision Brillouin gyroscope [14] would provide unprecedented sensitivity in measurements of the quantized circulation of the superfluid. Applied to conventional fluids, the same Brillouin process could be used to optically mix microdroplets and to probe their material properties, important tools for picolitre-scale chemistry, biophysics and the biosciences [37,38]. Moreover, strong phonon-mediated optical coupling may allow the generation of synthetic electromagnetic fields [12,13], and superfluid based optical switches and reconfigurable optical circuits [9,10].…”

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confidence: 99%

Strong optical coupling through superfluid Brillouin lasing

Harris

Baker

et al. 2020

Nat. Phys.

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Brillouin scattering has applications ranging from signal processing [1, 2], sensing [3] and microscopy [4], to quantum information [5] and fundamental science [6, 7]. Most of these applications rely on the electrostrictive interaction between light and phonons [3, 7, 8]. Here we show that in liquids optically-induced surface deformations can provide an alternative and far stronger interaction. This allows the demonstration of ultralow threshold Brillouin lasing and strong phonon-mediated optical coupling for the first time. This form of strong coupling is a key capability for Brillouin-reconfigurable optical switches and circuits [9, 10], for photonic quantum interfaces [11], and to generate synthetic electromagnetic fields [12, 13]. While applicable to liquids quite generally, our demonstration uses superfluid helium. Configured as a Brillouin gyroscope [14] this provides the prospect of measuring superfluid circulation with unprecedented precision, and to explore the rich physics of quantum fluid dynamics, from quantized vorticity to quantum turbulence [15, 16].Brillouin scattering is an optomechanical process that couples two optical waves via their interaction with travelling acoustic phonons. In the electrostrictive interaction usually employed, the optical electric field induces strain in a bulk medium, and the generated phonons scatter light between the two optical waves via refractive index changes caused by the medium's photoelasticity. However, the inherent weakness of this interaction presents a significant challenge [3], necessitating the use of high optical powers and prohibiting some applications. This can be alleviated by resonant enhancement in an optical cavity, which has allowed recent demonstrations of ultralow linewidth lasers [17, 18], Brillouin lasing in liquid droplets [8], non-reciprocal optical transport [19], Brillouin gyroscopes [14] and low-noise microwave oscillators [2]. Alternatively, optically-induced deformations of the boundary of the medium can be leveraged to provide a Brillouin interaction, with scattering induced by the effective refractive index-modulation caused by the deformation. In purpose-engineered solid structures these surface interactions can be made comparable to, or even exceed, the native electrostriction [20][21][22].Here, we transfer the concept of deformation-induced Brillouin scattering to liquid media, specifically a fewnanometer-thick superfluid helium film that coats the surface of a silica microdisk cavity and couples to its whispering gallery modes (see Fig. 1a,b) via perturbation of their evanescent field. Similar to other liquids [23], the superfluid film has an exceedingly weak restoring force, affording a compliant dielectric interface that easily deforms in the presence of optical forces [24, 25], as illustrated in Fig. 1c. This offers the potential for very large surface deformations and consequently extreme interaction strengths. We show that it allows radiation-pressure interactions with acoustic phonons that are over two orders of magnitude ...

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Brillouin Light Scattering: Applications in Biomedical Sciences

Cited by 129 publications

References 112 publications

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Strong optical coupling through superfluid Brillouin lasing

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