Brillouin spectroscopy imaging of cell phototoxic damage

Cheburkanov, Vsevolod; Purkayastha, Purboja; Pendyala, Kavya; Lele, Tanmay P.; Yakovlev, Vladislav V.

doi:10.1117/12.2610498

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A custom-built confocal Brillouin-Raman microscpectrometer was used (Figure 2). Optical layout, design and operation was extensively described in previous publications 11, 16 . Raman channel was used for targeting alone.…”

Section: Setup Descriptionmentioning

confidence: 99%

Investigating chemotherapy effects on peripheral nerve elasticity

Cheburkanov,

Du,

Berezin

et al. 2024

Visualizing and Quantifying Drug Distribution in Tissue VIII

Self Cite

View full text Add to dashboard Cite

Chemotherapy is one of the treatment methods aimed at killing cancer cells and hindering their metastasis. However, chemotherapy is known to induce multiple adverse side-effects. One of them is peripheral neuropathy, which causes significant discomfort to the cancer patient. It is hypothesized that neuropathy is directly linked to peripheral nerve damage or elasticity change. In this study we have attempted to use Brillouin spectroscopy to evaluate nerve elasticity changes and correlate them to the effects of chemotherapy.

show abstract

Section: Setup Descriptionmentioning

confidence: 99%

Investigating chemotherapy effects on peripheral nerve elasticity

Cheburkanov,

Du,

Berezin

et al. 2024

Visualizing and Quantifying Drug Distribution in Tissue VIII

Self Cite

View full text Add to dashboard Cite

show abstract

“…This approach has seen significant growth in the past decade with the techniques like Spontaneous Brillouin Spectroscopy and Impulsive Stimulated Brillouin Spectroscopy being applied to live cell imaging 6,7 , tissue imaging 8,9 and even organ-on-a-chip evaluation 10 . Recently a novel modification of Brillouin spectroscopic imaging technique has emerged, which has already been applied to efficient biologically relevant material evaluation 11 .…”

Section: Introductionmentioning

confidence: 99%

Label-free characterization of oxidative stress impact on drosophila brain elasticity using combined Brillouin-Raman spectroscopy

Cheburkanov

Willis

Yakovlev

2023

Label-Free Biomedical Imaging and Sensing (LBIS) 2023

View full text Add to dashboard Cite

Neurodegenerative diseases are currently among the most common causes for low quality of life among US population. In addition to that, disabilities caused by neurodegenerative diseases, negatively impact economy by causing early workforce retirement. Existing human models of such conditions are hard to replicate and describe due to the wide array of factors influencing the progression and morphology of the disease. Recent studies suggest application of photodynamically induced oxidative stress in drosophila model as a viable trigger to neurodegenerative conditions. We hypothesize that neural degradation is accompanied by significant changes in brain chemistry and biomechanics. This preliminary study focuses on investigation of correlation between drosophila brain elasticity and induced oxidative stress using combined Brillouin-Raman spectroscopy as a label-free method of elasticity measurement.

show abstract

Brillouin spectroscopy imaging of cell phototoxic damage

Cited by 2 publications

References 16 publications

Investigating chemotherapy effects on peripheral nerve elasticity

Investigating chemotherapy effects on peripheral nerve elasticity

Label-free characterization of oxidative stress impact on drosophila brain elasticity using combined Brillouin-Raman spectroscopy

Contact Info

Product

Resources

About