Brimonidine tartarate 0.2% (Alphagan) associated granulomatous anterior uveitis

Brimonidine Induced Anterior Uveitis

“…[2][3][4][5][6] In addition to conjunctivitis, sporadic case reports have emerged since 2000, of anterior uveitis in patients treated with topical brimonidine tartrate. [7][8][9][10][11][12][13][14][15][16][17] In this paper, we report 19 eyes affected by brimonidine induced uveitis, the largest series reported so far. We present the clinical characteristics of this under-diagnosed and easily treatable condition.…”

Granulomatous anterior uveitis associated with 0.2% topical brimonidine

“…Granulomatous anterior uveitis in association with topical brimonidine has been reported in only five patients since its introduction. 1,2 We report another case of bilateral granulomatous anterior uveitis developing as a late side effect of topical brimonidine therapy, providing further evidence of this potentially sight-threatening complication.…”

Brimonidine-induced Anterior Uveitis and Conjunctivitis

“…Photophobia, conjunctivitis, and corneal erosions and staining are occasional adverse effects. 5 Byles et al 6 suggest that anterior uveitis secondary to brimonidine therapy may be an immunologic extension of the ocular intolerance experienced by people who demonstrate a predisposition to this adverse effect. This is consistent with our patient's history of papillary conjunctivitis, and those histories from previous case reports.…”

“…This is consistent with our patient's history of papillary conjunctivitis, and those histories from previous case reports. [5][6][7][8][9] The current literature comprises a collection of case reports originating from September 2000 when Byles et al documented 4 cases of anterior uveitis as a side effect of brimonidine therapy after a mean usage interval of 14 months. All cases resolved on cessation of brimonidine (in some cases continuing adjuvant ocular antihypertensive medication) and prescription of a topical steroid.…”