Brincidofovir (CMX001) for the Treatment of Severe Adenoviral Pneumonia in Kidney Transplant Recipient

Sudhindra, Praveen; Knoll, Bettina M.; Nog, Rajat; Singh, Neil; Dhand, Abhay

doi:10.7759/cureus.5296

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…For HMPV infection, treatment is mainly supportive, although ribavirin, intravenous immunoglobulin, monoclonal antibodies, and fusion inhibitory peptides against specific viral proteins have been used in isolated cases or in experimental models ( 229 – 234 ). Cidofovir and its oral prodrug brincidofovir are administered in severe HAdV infections ( 164 , 235 – 237 ).…”

Section: Treatmentmentioning

confidence: 99%

“…For HMPV infection, treatment is mainly supportive, although ribavirin, intravenous immunoglobulin, monoclonal antibodies, and fusion inhibitory peptides against specific viral proteins have been used in isolated cases or in experimental models (229)(230)(231)(232)(233)(234). Cidofovir and its oral prodrug brincidofovir are administered in severe HAdV infections (164,(235)(236)(237). In contrast to respiratory infections, targeted antivirals are available for major CNS pathogens like HSV and VZV viruses ( Table 7).…”

Section: Antiviralsmentioning

confidence: 99%

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Update in Viral Infections in the Intensive Care Unit

et al. 2021

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The advent of highly sensitive molecular diagnostic techniques has improved our ability to detect viral pathogens leading to severe and often fatal infections that require admission to the Intensive Care Unit (ICU). Viral infections in the ICU have pleomorphic clinical presentations including pneumonia, acute respiratory distress syndrome, respiratory failure, central or peripheral nervous system manifestations, and viral-induced shock. Besides de novo infections, certain viruses fall into latency and can be reactivated in both immunosuppressed and immunocompetent critically ill patients. Depending on the viral strain, transmission occurs either directly through contact with infectious materials and large droplets, or indirectly through suspended air particles (airborne transmission of droplet nuclei). Many viruses can efficiently spread within hospital environment leading to in-hospital outbreaks, sometimes with high rates of mortality and morbidity, thus infection control measures are of paramount importance. Despite the advances in detecting viral pathogens, limited progress has been made in antiviral treatments, contributing to unexpectedly high rates of unfavorable outcomes. Herein, we review the most updated data on epidemiology, common clinical features, diagnosis, pathogenesis, treatment and prevention of severe community- and hospital-acquired viral infections in the ICU settings.

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Section: Treatmentmentioning

confidence: 99%

“…For HMPV infection, treatment is mainly supportive, although ribavirin, intravenous immunoglobulin, monoclonal antibodies, and fusion inhibitory peptides against specific viral proteins have been used in isolated cases or in experimental models (229)(230)(231)(232)(233)(234). Cidofovir and its oral prodrug brincidofovir are administered in severe HAdV infections (164,(235)(236)(237). In contrast to respiratory infections, targeted antivirals are available for major CNS pathogens like HSV and VZV viruses ( Table 7).…”

Section: Antiviralsmentioning

confidence: 99%

Update in Viral Infections in the Intensive Care Unit

et al. 2021

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“…However, cidofovir is often associated with high levels of nephrotoxicity [ 8 , 9 , 10 ]. Brincidofovir (CMX001, Chimerix Inc., Durham, NC, USA), a lipid conjugate of cidofovir, has improved oral bioavailability and reduced nephrotoxicity [ 11 , 12 ], but has been associated with gastrointestinal toxicity [ 12 ]. Immunotherapy using anti-HAdV T-cells has shown some early success in bone marrow transplant patients, but studies are still ongoing and there is a lack of data on the effectiveness of this therapy in solid organ transplant patients [ 5 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Effects of Curcumin on Adenovirus Replication

Jennings

Parks

2020

Microorganisms

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Human adenovirus (HAdV) is a common pathogen that can cause severe morbidity and mortality in certain populations, including pediatric, geriatric, and immunocompromised patients. Unfortunately, there are no approved therapeutics to combat HAdV infections. Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different bacteria and viruses. In this study, we evaluated curcumin as an anti-HAdV agent. Treatment of cells in culture with curcumin reduced HAdV replication, gene expression, and virus yield, at concentrations of curcumin that had little effect on cell viability. Thus, curcumin represents a promising class of compounds for further study as potential therapeutics to combat HAdV infection.

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“…Various molecules (cidofovir, brincidofovir, ganciclovir, valganciclovir) exert an antiviral effect on HAdV. However, there is no consensus antiviral therapeutic approach, and strategies are mainly based on case reports [ 289 , 292 ].…”

Section: Othersmentioning

confidence: 99%

Virus-Associated Nephropathies: A Narrative Review

Masset

Turnier

Bressollette-Bodin

et al. 2022

IJMS

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While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity or direct or indirect viral-associated nephropathy. We review here the described virus-associated nephropathies in order to guide diagnosis strategies and treatments in cases of acute kidney injury (AKI) occurring concomitantly with a viral infection. The occurrence of virus-associated nephropathy depends on multiple factors: the local epidemiology of the virus, its ability to infect renal cells and the patient’s underlying immune response, which varies with the state of immunosuppression. Clear comprehension of pathophysiological mechanisms associated with a summary of described direct and indirect injuries should help physicians to diagnose and treat viral associated nephropathies.

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Brincidofovir (CMX001) for the Treatment of Severe Adenoviral Pneumonia in Kidney Transplant Recipient

Cited by 11 publications

References 18 publications

Update in Viral Infections in the Intensive Care Unit

Update in Viral Infections in the Intensive Care Unit

Antiviral Effects of Curcumin on Adenovirus Replication

Virus-Associated Nephropathies: A Narrative Review

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