Due to the increasing limitations of water resources, application of desalination plants is expanding. One of the constraints associated with desalination plant operation is the production of concentrated solution, which is known as brine and can lead to critical challenges in the environment due to its high level of salinity. In this regard, many different disposal options used recently to control and prevent the environmental issues may be caused by the brine. Evaporation ponds, surface water discharge, and deep well injection are considered as the most well-known options to properly dispose concentrated brine. However, the application of these methods is highly restricted by capital cost and their limited uses. The treatment methods vary in terms of their ability in organics removal and can be divided into three different conventional groups as biological, physicochemical, and oxidation. In recent years, more attention has been paid to membrane-based technologies due to their economic performance in recovering precious resources and providing potable water with high recovery rates. This book chapter provides some critical reviews on recent technologies including treatment operations and disposal options to manage concentrated solutions from desalination plants. Finally, electrodialysis, forward osmosis, and membrane distillation as emerging membrane processes are examined in this chapter.