Brine shrimp toxicity of acidic fractions of &lt;i&gt; Boswellia dalzielii&lt;/i&gt; gum resin

Alemika, Taiwo E.; Ojerinde, Stephen O.

doi:10.4314/jpb.v2i2.32077

Cited by 5 publications

(10 citation statements)

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“…Consistent with findings from previous studies [39, 40], the present results clearly demonstrated an improvement in lipid profile associated with BA administration. Another explanation could be afforded by Ali and Mansour [41], who emphasized that platelet hyperaggregability associated with HFD was prevented by the use of an antioxidant, indicating the critical role for intracellular ROS in this phenomenon.…”

Section: Discussionsupporting

confidence: 93%

Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades

Tawfik

2016

aoms

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IntroductionA high-fat diet is one of the main dietary factors promoting platelet aggregation. The present study was conducted to elucidate the involvement of boswellic acid (BA) on the platelet hyperaggregability in HFD-fed rats. As platelet hyperaggregability in HFD rats is closely linked to inflammation and enhanced free radical production, the present study was extended to evaluate the anti-inflammatory and anti-oxidative effect of BA on HFD-promoted platelet aggregation.Material and methodsRats were assigned to normal, HFD-fed, aspirin-treated (30 mg/kg), and BA-treated (250 and 500 mg/kg) groups.ResultsBoswellic acid administration in a high dose was effective in attenuating the severity of hyperlipidemia and platelet aggregation, indicated by lower collagen/epinephrine-induced platelet aggregation, as evidenced by the significant increase (p < 0.05) in the circulating platelet count and reduction in the number of thrombi in the lungs. Moreover, it attenuated the oxidative stress and the intensity of inflammatory mediators associated with platelet hyperaggregability, as evidenced by the inhibitory effects on interlukin-1β, COX-2 and tumor necrosis factor-α, indicating that the antiplatelet activity of BA is likely a consequence of controlling oxidative stress and inflammation.ConclusionsThe present data suggest that BA shows a promising anti-aggregatory effect by attenuating the enhanced hyperlipidemia, oxidative stress and inflammation associated with HFD.

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Section: Discussionsupporting

confidence: 93%

Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades

Tawfik

2016

aoms

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“…Boswellia dalzieli (family: Burceracaea) commonly known as Frankincense tree is a deciduous tree propagated by seed and which grows to the height of 12 meters Pwol, 2007: Alemika andOjerinde, 2005). It is the West African species of the true Frankincense tree.…”

Section: Background Of the Studymentioning

confidence: 99%

Effect of Repeated Dose Administration of Ethanolic Extract of Bosweillia dalzielii Stem Bark on Haematological Parameters of Normoglycaemic and Alloxan Induced Hyperglycaemic Albino Rats

Etteh

2024

Preprint

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Boswelia dalzielii (family Burseraceae) is the West African species of the frankincense producing genres. Its ethnomedicinal applications include the treatment of emesis, heart diseases, leprosy and diabetes mellitus. Ethanolic extract of the plant was investigated for their anti-hyperglycaemic properties and their effect on haematological parameters of normglycemic and alloxan-induced hyperglycaemic albino rats. The study showed a statistically significant P<0.05) reduction of blood glucose concentration in the diabetic experimental animals proceeding from day 2 through day 7 of extract administration and in the normoglycemic (non-diabetic) rats starting from day 5 through day 7. Assessment of the ethanolic extract of the plant on haematological parameters showed significant (p<0.05) reduction in circulating RBC, Hb, MCH and MCHC but an increase in MCV of the hyperglycaemic rats. Total white blood cell (WBC) count and monocyte (MONO) decreased significantly (p<0.05) while lymphocyte increased significantly |p<0.05) astreatment progressed. The result of the present study suggests that ethanolic extract of B . dalzielii possess antihyperglycaemic properties. However, while the plant may be useful for the treatment of diabetes mellitus, it has been shown to educe the number of circulating red blood cells, haemoglobin and white blood cells in diabetic animals.

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“…Extracts demonstrated antifungal, anti-inflammatory, cytotoxic, antiproliferative and hypoglycemic effects [4,7,8,13]. The gum resin (frankincense) showed anti-inflammatory activity and yielded volatile oil consisting mainly of monoterpenes (fragrant essence) [14].…”

Section: -O-acetyl-11-keto-β-boswellic Acid (Akba)mentioning

confidence: 99%

Potential Application of the West African frankincense, Boswellia dalzielii Hutch, for Drug and Perfumery Products

2018

JAPM

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Boswellia dalzielii is the West African species of the frankincense producing genus (B. carterii, B. frereana and B. serrata are the more popular congeners). Its ethnobotanical uses include the treatment of rheumatism, venereal diseases and gastro-intestinal disorders, among others.Scientific investigations were carried out to evaluate the biological properties relevant to their ethnomedical uses and to better understand the chemistry of the plant. This is with a view to identifying possible applications for medicinal, cosmetic and industrial purposes. The stem bark was subjected to solvent extraction and activity-directed fractionation to isolate bioactive compounds. The isolated compounds were characterised using joint spectroscopic techniques, including 2-D NMR and Mass Spectrometry. The gum resin was steam-distilled to obtain volatile oil, which was analysed by GC-MS. Another portion of gum resin was also extracted by organic solvent and fractionated by column chromatography. From the results obtained; the antimicrobial/antioxidant activity of the stem bark was accounted for by isolated compounds – protocatechuic acid, gallic acid and ethyl gallate with minor contribution from a novel stilbene glycoside and a cembranediterpenoid (incensole). The extracts also demonstrated antifungal, anti-inflammatory, cytotoxic and hypoglycemic effects. The gum resin (frankincense) showed anti-inflammatory activity and yielded volatile oil consisting mainly of monoterpenes (fragrant essence). The gum resin extract yielded incensole and 3-O-acetyl-11-ketoboswellic acid (AKBA). The spectrum of biological activities observed justifies the ethnomedical uses and suggests great potential for further drug development. The essential oil can be employed in perfumery products and in related industry

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Brine shrimp toxicity of acidic fractions of <i> Boswellia dalzielii</i> gum resin

Cited by 5 publications

References 0 publications

Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades

Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades

Effect of Repeated Dose Administration of Ethanolic Extract of Bosweillia dalzielii Stem Bark on Haematological Parameters of Normoglycaemic and Alloxan Induced Hyperglycaemic Albino Rats

Potential Application of the West African frankincense, Boswellia dalzielii Hutch, for Drug and Perfumery Products

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