Bringing Again Noble Metal Nanoparticles to the Forefront of Cancer Therapy

Vlamidis, Ylea; Voliani, Valerio

doi:10.3389/fbioe.2018.00143

Cited by 59 publications

(40 citation statements)

References 47 publications

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“…In recent years, nanoparticles gained increasing attention as suitable tools for the diagnosis and treatment of neoplasms. 28 Indeed, they have demonstrated some advantages in theranostics, among which increased drug encapsulation features and specific site delivery if properly conjugated with targeting agents. 14 However, it is difficult to understand if nanomaterials are able to be effectively internalized in depth in a tumor by only using 2D cell cultures.…”

Section: Anticipated Resultsmentioning

confidence: 99%

Production of 3D Tumor Models of Head and Neck Squamous Cell Carcinomas for Nanotheranostics Assessment

Santi

Mapanao

Cappello

et al. 2020

ACS Biomater. Sci. Eng.

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As a first approach, standard 2D cell culture techniques are usually employed for the screening of drugs and nanomaterials. Despite the easy handling, findings achieved on 2D cultures are often not efficiently translatable to in vivo preclinical investigations. Furthermore, although animal models are pivotal in preclinical studies, more strict directives have been implemented to promote the use of alternative biological systems. In this context, the development and integration into preclinical research workflow of 3D neoplasm models is particularly appealing to promote the advancement and success of therapeutics in clinical trials while reducing the number of in vivo models. Indeed, 3D tumor models bridge several discrepancies between 2D cell culture and in vivo models, among which are morphology, polarity, drug penetration, osmolality, and gene expressions. Here, we comprehensively describe a robust and high-throughput hanging drop protocol for the production of 3D models of both Human Papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinomas (HNSCCs). We also report the standard cascade assays for their characterization and demonstrate their significance in investigations on these aggressive neoplasms. The employment of relevant 3D cancer models is pivotal to produce more reliable and robust findings in terms of biosafety, theranostic efficacy, and biokinetics as well as to promote further knowledge on HNSCC pathophysiology.

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Section: Anticipated Resultsmentioning

confidence: 99%

Production of 3D Tumor Models of Head and Neck Squamous Cell Carcinomas for Nanotheranostics Assessment

Santi

Mapanao

Cappello

et al. 2020

ACS Biomater. Sci. Eng.

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“…Metal nanoparticles (NPs) have been recently proposed for an increasing number of applications in nano-medicine (Vlamidis and Voliani, 2018) and nanotechnology (Chen et al, 2015). For instance, gold NPs (Alex and Tiwari, 2015) allow covalent versatile functionalization via thiol chemistry (Hakkinen, 2012) with different biomolecules or functional groups to selectively favor interactions with proteins or other specific components of the cell milieu.…”

Section: The Landscape Of Coarse Grained Np Modelsmentioning

confidence: 99%

Building Minimalist Models for Functionalized Metal Nanoparticles

Brancolini

Tozzini

2019

Front. Mol. Biosci.

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“…Nanomaterials were studied in vitro and in vivo, and some reached clinical trials. Those include poly (lactic-co-glycolic acid) (PLGA) nanoparticles, metallic nanoparticles, carbon nanotubes and nanoparticles, polymer-and lipid-based materials, and many others [1][2][3][4] . Generally, it seems that the involvement of nanoparticles in designed drug formulae could be indeed beneficial to fight resistant cancer (and CSC) cells.…”

Section: Introductionmentioning

confidence: 99%

Why nanodiamond carriers manage to overcome drug resistance in cancer

Benson¹,

Amini²

2020

CDR

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Nanodiamonds represent an attractive potential carrier for anticancer drugs. The main advantages of nanodiamond particles with respect to medical applications are their high compatibility with non-cancerous cells, feasible surface decoration with therapeutic and cancer-cell targeting molecules, and their relatively low manufacturing cost. Additionally, nanodiamond carriers significantly increase treatment efficacy of the loaded drug, so anticancer drugs execute more effectively at a lower dose. Subsequently, lower drug dose results in less extensive side effects. The carriers decorated with a targeting molecule accumulate primarily in the tumor tissue, and those nanodiamond particles impair efflux of the drug from cancer cells. Therapeutic approaches considering nanodiamond carriers were already tested in vitro , as well as in vivo. Now, researchers focus particularly on the possible side effects of nanodiamond carriers applied systemically in vivo. The behavior of nanodiamond carriers depends heavily on their surface coatings, so each therapeutic complex must be evaluated separately. Generally, it seems that site-specific application of nanodiamond carriers is a rather safe therapeutic approach, but intravenous application needs further study. The benefits of nanodiamond carriers are remarkable and represent a potent approach to overcome the drug resistance of many cancers.

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Bringing Again Noble Metal Nanoparticles to the Forefront of Cancer Therapy

Cited by 59 publications

References 47 publications

Production of 3D Tumor Models of Head and Neck Squamous Cell Carcinomas for Nanotheranostics Assessment

Production of 3D Tumor Models of Head and Neck Squamous Cell Carcinomas for Nanotheranostics Assessment

Building Minimalist Models for Functionalized Metal Nanoparticles

Why nanodiamond carriers manage to overcome drug resistance in cancer

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