Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends

Sanjarnia, Pegah; Picchio, Matías L.; Polegre Solis, Agustin N.; Schuhladen, Katharina; Fliss, Patricia M.; Politakos, Nikolaos; Metterhausen, Lutz; Calderón, Marcelo; Osorio-Blanco, Ernesto R.

doi:10.1016/j.addr.2024.115217

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115217

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Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends

Pegah Sanjarnia,

Matías L. Picchio,

Agustin N. Polegre Solis

et al.

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Cited by 13 publications

References 287 publications

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Khattak,

Ullah,

Sohail

et al. 2024

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Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. These complex conditions complicate effective wound management, prompting the development of advanced diabetic wound care strategies that exploit specific wound characteristics such as acidic pH, high glucose levels, and oxidative stress to trigger controlled drug release, thereby enhancing the therapeutic effects of the dressings. Among the solutions, hydrogels emerge as promising due to their stimuli‐responsive nature, making them highly effective for managing these wounds. The latest advancements in mono/multi‐stimuli‐responsive smart hydrogels showcase their superiority and potential as healthcare materials, as highlighted by relevant case studies. However, traditional wound dressings fall short of meeting the nuanced needs of these wounds, such as adjustable adhesion, easy removal, real‐time wound status monitoring, and dynamic drug release adjustment according to the wound's specific conditions. Responsive hydrogels represent a significant leap forward as advanced dressings proficient in sensing and responding to the wound environment, offering a more targeted approach to diabetic wound treatment. This review highlights recent advancements in smart hydrogels for wound dressing, monitoring, and drug delivery, emphasizing their role in improving diabetic wound healing. It addresses ongoing challenges and future directions, aiming to guide their clinical adoption.

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Khattak,

Ullah,

Sohail

et al. 2024

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Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review

Li,

Ahmed,

Hussein

et al. 2024

Archiv der Pharmazie

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Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. These biopolymers possess unique physicochemical (such as surface functional groups, solubility, and stability), mechanical (like mechanical strength and tensile), and biomedical (such as antioxidant activity, biocompatibility, biodegradability, renewability, and non‐immunogenicity) characteristics which have made them excellent platforms for a wide variety of biomedical and pharmaceutical applications. Ease of extraction and different preparation approaches are mentioned as other potential properties of polysaccharides that further improved their practicality in biomedical sciences. They have high drug/bioactive encapsulation capacity and sustained/controlled release manner in in vivo microenvironments. The anti‐inflammatory and immunomodulation, stimuli‐responsive drug/bioactive release, and passive and active drug/bioactive delivery are considered the potential features of these biopolymers in pharmaceutical sciences. Polysaccharides have indicated practical applications in biomedical sciences, including biosensors, tissue engineering, implantation, wound healing, vascular grafting, and vaccines. This review highlights the advances of polysaccharide‐based materials in biomedical and pharmaceutical sciences.

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Next generation concepts in dermal delivery, theranostics, and preclinical testing

Hedtrich,

Calderón

2024

Advanced Drug Delivery Reviews

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Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends

Cited by 13 publications

References 287 publications

Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review

Next generation concepts in dermal delivery, theranostics, and preclinical testing

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