The rapid spread of the COVID-19 pandemic and the associated infection control measures imposed by governments caused a major disruption to traditional workflows, leading to an immense increase in remote work. At the same time, innovation activities became more collaborative and digitalized than ever before, as firms worldwide were forced to shift from physical to virtual innovation spaces literally overnight and suddenly had to adapt and practice “remote innovation”. By means of a systematic literature review based on 80 selected articles, this paper contributes to the academic discussion in three ways: First, the paper explores the synthesis between open innovation and remote work and uncovers a set of necessary determinants that form the basis for practicing remote innovation. Second, the paper offers a conceptual framework based on Chesbrough’s open innovation model and extended by various determinants of open innovation in a remote work environment to provide initial advice to managers on how to innovate in times of social distancing. Third, the study concludes by identifying several promising areas for future research in the field of remote innovation management, a hitherto under-researched but highly topical field.