Brisket Disease. Iii. Spontaneous Remission of Pulmonary Hypertension and Recovery From Heart Failure*

Kuida, Hiroshi; Hecht, Hans H.; Lange, Ramon L.; Brown, Arthur M.; Tsagaris, Theofilos J.; Thorne, Joseph L.

doi:10.1172/jci104749

Cited by 24 publications

(7 citation statements)

References 9 publications

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“…Peiialoza and associates have also reported reversibility of hypoxic pulmonary hypertension in residents of Morococha, Peru (14,900 ft) after moving to Lima, Peru (500 ft) (10). Similarly, Kuida and associates have demonstrated reversibility of hypoxic pulmonary hypertension in calves with brisket disease upon going to lower altitude (11). In contrast to our studies, however, they did not observe recurrent hypertension when their animals were returned to high altitude.…”

Section: Discussioncontrasting

confidence: 82%

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Effects of Mild Chronic Hypoxia on the Pulmonary Circulation in Calves with Reactive Pulmonary Hypertension

Vogel

McNamara

Hallman

et al. 1967

Circulation Research

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The effects of the mild hypoxia at an altitude of 5280 ft on the pulmonary circulation were examined in normal calves and calves with a preexisting stimulus to maintain a reactive pulmonary vascular bed. In a serial study, 9 calves born at 5280 ft and 9 calves born at sea level underwent left pulmonary artery (LPA) ligation; 3 calves born at 5280 ft and 8 calves born at sea level underwent right pulmonary artery (RPA) ligation within 24 to 48 hours after birth. Progressive pulmonary hypertension and right ventricular heart failure developed in all calves operated on at 5280 ft but not in those with LPA ligation performed at sea level until they were transferred to 5280 ft. In contrast, in some animals with RPA ligation at sea level, progressive pulmonary hypertension was noted. The increased pulmonary blood flow consequent to LPA ligation does not result in progressive pulmonary hypertension at sea level but the addition of the mild hypoxia at 5280 ft appears to provide additional sufficient stimulus to result in progressive pulmonary hypertension. However, the slightly higher pulmonary blood flow subsequent to RPA ligation is capable of producing progressive pulmonary hypertension at sea level. Correlation was found between these results and human patients with congenital unilateral absence of a pulmonary artery, indicating that, in subjects with some stimulus to maintain a reactive pulmonary vascular bed, the mild hypoxia of 5280 ft may exert a significant effect on the pulmonary circulation.ADDITIONAL KEY WORDS unilateral pulmonary artery ligation heart failure altitude vascular reactivity• In this paper, using observations in calves with unilateral pulmonary artery ligation, it will be shown that the mild hypoxia at 5280 ft (Denver, Colorado), as contrasted to sea level (Houston, Texas), may significantly alter the pulmonary circulation.

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Section: Discussioncontrasting

confidence: 82%

“…Six normal calves remaining at sea level had retained normal pulmonary arterial pressures (20 to 32 mm Hg) after 228 to 448 days (no. [9][10][11][12][13][14].…”

Section: Houstonmentioning

confidence: 99%

Effects of Mild Chronic Hypoxia on the Pulmonary Circulation in Calves with Reactive Pulmonary Hypertension

Vogel

McNamara

Hallman

et al. 1967

Circulation Research

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“…14 ' 15 In fact, pulmonary hypertension persists after hypervolemia and polycythemia have disappeared. 14 An increased medial muscle mass in individual pulmonary arteries is not the only vascular abnormality found in children at high altitude.…”

Section: Discussionmentioning

confidence: 99%

Children at High Altitude: Pulmonary and Renal Abnormalities

Naeye

1965

Circulation Research

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Changes in pulmonary arteries and renal glomeruli were assessed in children born and resident at high altitude (Leadville, Colorado). The hypoxia appears to arrest normal neonatal decrease of pulmonary arterial smooth muscle in some of these children. No abnormalities were found in pulmonary veins or capillaries. A quantitative study also demonstrated enlargement of renal glomeruli in the hypoxic children after the first month of life, apparently due to a proliferation of normal glomerular elements.

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“…Acidosis, per se, does not influence ventricular performance (Talner, Garner, and Downing, 1966), but the degree of depression of ventricular performance imposed by a given level of hypoxia is potentiated by acidosis (Downing, Talner, and Gardner, 1965). An increase in the left ventricular end-diastolic pressure has been described in some forms of hypoxic heart disease (Kuida et al, 1963;Hecht, Kuida, and Tsagaris, 1962). Although the clinical picture in these children was dominated by signs of right heart failure, cine-angiographic studies in some suggested that there might also have been an element of left ventricular dysfunction.…”

Section: Clinical Featuresmentioning

confidence: 98%

Large tonsils and adenoids in small children with cor pulmonale.

Ainger¹

1968

Heart

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Brisket Disease. Iii. Spontaneous Remission of Pulmonary Hypertension and Recovery From Heart Failure*

Cited by 24 publications

References 9 publications

Effects of Mild Chronic Hypoxia on the Pulmonary Circulation in Calves with Reactive Pulmonary Hypertension

Effects of Mild Chronic Hypoxia on the Pulmonary Circulation in Calves with Reactive Pulmonary Hypertension

Children at High Altitude: Pulmonary and Renal Abnormalities

Large tonsils and adenoids in small children with cor pulmonale.

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