Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model

Kim, Sun-Gun; Lee, Eujin; Park, Na-Young; Park, Hyo-Hyun; Jeong, Kyu-Tae; Kim, Keuk‐Jun; Lee, Youn Ju; Jin, Meihua; Lee, Eunkyung

doi:10.1007/s12272-016-0783-z

Cited by 22 publications

(16 citation statements)

References 19 publications

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“…Statistical differences were assessed via the IBM SPSS Statistics v. 19.0.0 (New York, NY, USA) software. The normality of the distributions was evaluated via the Kolmogorov-Smirnov test.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Britanin can also inhibit degranulation and eicosanoid production in IgE/Ag‐induced bone marrow‐derived mast cells, supporting that this may be the mechanism by which it affects allergic inflammation . In a recent report, the therapeutic effect of Britanin on ovalbumin (OVA)‐induced airway inflammation has been demonstrated, corresponding to the anti‐asthma activity of Inulae Flos . In addition to its foreseeable use as an anti‐allergy and anti‐inflammatory agent, Britanin could also protect neural tissue from reperfusion injury following oxygen–glucose deprivation .…”

Section: Introductionmentioning

confidence: 99%

“…[18] In a recent report, the therapeutic effect of Britanin on ovalbumin (OVA)-induced airway inflammation has been demonstrated, corresponding to the anti-asthma activity of Inulae Flos. [19] In addition to its foreseeable use as an anti-allergy and anti-inflammatory agent, Britanin could also protect neural tissue from reperfusion injury following oxygenglucose deprivation. [20] Based on the reported biological activity of Britanin, it is reasonable to speculate that it is the active compound from the plant.…”

Section: Introductionmentioning

confidence: 99%

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In vivo antitumour activity of Britanin against gastric cancer through nuclear factor-κB-mediated immune response

Shi

Cai

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Britanin was explored for the antitumour effect on gastric cancer, which is a sesquiterpene lactone (SL) extracted from Inula japonica. Methods In the present study, cell viability assays were performed to evaluate the antiproliferation effect of Britanin on gastric cancer cells. Tumour development in BGC‐823 cell‐bearing nude mice was monitored in real‐time after Britanin treatment via a bioluminescent imaging method. Western blotting analysis and enzyme‐linked immunosorbent assays detected proteins associated with the nuclear factor (NF)‐κB signalling pathway. Key findings Britanin can suppress the proliferation of gastric cancer cells in vitro and the growth of tumours in vivo. In the treatment group, decreased levels of p65 and phosphorylated (p)‐p65 were observed. This indicated that NF‐κB plays an important role in the antitumour effect of Britanin. Furthermore, considering the additional role of NF‐κB in the immune system, the levels of the downstream molecules interleukin (IL)‐2 and the cytokine IL‐10 were subsequently determined in vivo. An increase in the IL‐2 level and a decrease in the IL‐10 level indicated that Britanin elicited an enhanced immune response. Conclusions Britanin may be a promising candidate for gastric cancer chemotherapy, and its anticancer effect likely depends on an NF‐κB‐mediated immune response.

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“…Statistical differences were assessed via the IBM SPSS Statistics v. 19.0.0 (New York, NY, USA) software. The normality of the distributions was evaluated via the Kolmogorov-Smirnov test.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo antitumour activity of Britanin against gastric cancer through nuclear factor-κB-mediated immune response

Shi

Cai

et al. 2020

Journal of Pharmacy and Pharmacology

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“…The results indicated that limethason notably prevented inflammatory cell infiltration, and was more effective compared with dexamethasone. It is generally accepted that eosinophils are the primary leukocyte to infiltrate in OVA-induced mice ( 25 ). Thus, in the present study, the percentage of different leukocyte types was measured in BALF.…”

Section: Discussionmentioning

confidence: 99%

Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects

Miao

Wang

et al. 2018

Exp Ther Med

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Airway inflammation is the major pathological feature of asthma. Thus, the current therapeutic strategy for asthma is to control inflammation. Limethason, an anti-inflammation drug, is widely used in rheumatoid arthritis treatment. The aim of the present study was to detect the anti-inflammatory effect and side effects of limethason on airways that were sensitized with ovalbumin in a murine model of chronic asthma. In the present study, BALB/c mice were sensitized with ovalbumin. Airway hyperresponsiveness was estimated, and hematoxylin and eosin staining, Periodic acid-Schiff staining and bronchoalveolar lavage were used to detect the effect on chronic asthma. Limethason effectively reduced airway hyperresponsiveness, and inhibited inflammatory cell infiltration and mucus secretion. Bronchoalveolar lavage fluid analysis revealed that limethason suppressed levels of airway eosinophils. In the period of treatment, limethason exhibited no influence on morphology of the femoral head, bone mineral content or bone mineral density, which were detected by histological studies and dual-energy X-ray absorptiometry. The index of liver, spleen, kidney, gastrocnemius and brown adipose tissue also demonstrated that limethason had no adverse effects on organs and tissues. The present study revealed that limethason could effectively reduce inflammation in an asthma mouse model without side effects. Therefore, limethason may have therapeutic potential for treating chronic asthma clinically.

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“…1) is a bioactive sesquiterpene lactone isolated from the aerial portions of Inula lineariifolia (Genus: Inula; Family: Asteraceae) [6]. Previous pharmacological studies of britanin primarily established its antioxidant, anti-inflammation, and cerebroprotective effects [7][8][9][10][11]. However, few studies have been conducted in the anticancer field.…”

Section: Introductionmentioning

confidence: 99%

Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways

Zeng

et al. 2020

Planta Med

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Britanin, a natural pseudoguaiacane sesquiterpene lactone, has significant antioxidant and anti-inflammatory activity, but little is known about its tumor inhibitory activity and the underlying mechanism. Here, we demonstrated in vitro and in vivo that britanin inhibited the growth of human prostate cancer cell lines (PC-3, PC-3-LUC, and DU-145). Through in vitro study, the results showed that britanin significantly decreased cell proliferation, migration, and motility. The moderate toxicity of britanin was determined with an acute toxicity study. A luciferase-labeled animal tumor xenograft model and bioluminescence imaging were applied, combining with biological validation for assessing the tumor progression. In vivo results demonstrated that britanin inhibited the growth of PC-3-LUC. The interleukin-2 level in mice was upregulated by britanin, which indicated that britanin induced antitumor immune activation. In addition, britanin downregulated the expression of nuclear factor (NF)-κB p105/p50, pp65, IκBα, pIκBα, phosphoinositide 3-kinase, pPI3k, Akt (protein kinase B, PKB), and pAkt proteins and upregulated expression of Bax. We discovered that britanin inhibits the growth of prostate cancer cells both in vitro and in vivo by regulating PI3K/Akt/NF-κB-related proteins and activating immunity. These findings shed light on the development of britanin as a promising agent for prostate cancer therapy.

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Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model

Cited by 22 publications

References 19 publications

In vivo antitumour activity of Britanin against gastric cancer through nuclear factor-κB-mediated immune response

In vivo antitumour activity of Britanin against gastric cancer through nuclear factor-κB-mediated immune response

Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects

Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways

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