British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis

Tasca, R A; McCormick, M; Clarke, R. W.

doi:10.1016/j.ijporl.2005.12.003

Cited by 39 publications

(24 citation statements)

References 17 publications

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“…Various lasers, including CO 2 , KTP, and pulsed dye, are the preferred method of surgical removal of RRP in children [66]. Adjuvant pharmacologic medical therapies with the antiviral agent cidofovir or interferon can also be used [20].…”

Section: Management-treatmentmentioning

confidence: 99%

Human papilloma virus (HPV) infection in children and adolescents

2008

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Human papilloma viruses (HPV) are common pathogens associated with a wide range of cutaneous and mucosal infections in childhood. Different HPV types can cause common warts, genital warts, low-grade as well as high-grade squamous intraepithelial lesions. Anogenital warts represent an issue with legal and clinical implications and evaluation of children for the possibility of sexual abuse should be considered in all cases. Recurrent respiratory papillomatosis has also been associated with HPV infection in a variety of studies. The recently introduced HPV vaccination is expected to prevent HPV-related cervical cancer in adulthood; however, HPV infection will continue to affect children.

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Section: Management-treatmentmentioning

confidence: 99%

Human papilloma virus (HPV) infection in children and adolescents

2008

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“…Some of the factors associated with the more aggressive form of the disease have already been established: infection with HPV 11, early spread of the papillomas to the subglottis, the onset of the disease before the age of 3 years, gastroesophageal reflux and a simultaneous infection with other viruses [2,[11][12][13]. In the case of an aggressive disease, adjuvant therapy is used in most centers [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Surgical debulking of the papillomas under general anesthesia is still the basic mode of treatment for RRP [14,16]. Adjuvant pharmacotherapy is used in up to 30 % of pediatric patients with RRP, with cidofovir and interferon alpha being applied in more than two-thirds of the cases [14,15,17,18].…”

Section: Introductionmentioning

confidence: 99%

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Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Boltežar

Matičič

Šereg-Bahar

et al. 2014

Eur Arch Otorhinolaryngol

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In the case of an aggressive course of recurrent respiratory papillomatosis (RRP), adjuvant therapy can be used besides surgery. The aim of the study was to investigate the influence of vaccination with a quadrivalent vaccine against human papilloma viruses (HPV) types 6, 11, 16 and 18 on the course of RRP. Eleven subjects aged 13-46 years with a rapid growth of laryngeal papillomas were included in the study. They were vaccinated with three doses of the quadrivalent prophylactic HPV vaccine (Silgard(®), MSD) and followed up for 12-52 months. The intervals between the successive surgical procedures, the extension of the disease (Derkay score) at each surgery, and the number of surgical procedures per year before vaccination and after its completion were compared. The mean interval between the surgical procedures was 271.2 days before the vaccination and 537.4 days after it (p = 0.034). The mean number of surgeries per year was 2.16 before the vaccination and 0.93 after it (p = 0.022). The Derkay score did not change significantly after vaccination. Complete remission of the disease was observed in one patient, partial response to the vaccination was observed in seven patients and no response was observed in three patients. In conclusion, vaccination with the quadrivalent HPV vaccine can favorably influence the course of RRP in patients with the rapid growth of the papillomas. It significantly prolongs the intervals between the surgical procedures and reduces the number of procedures needed in the majority of patients. The present investigation can serve as a pilot study for further research. For a final conclusion a longer follow-up and studies on more patients are necessary.

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“…6 In order to reduce or eliminate the need for future surgical procedures, several adjuvant therapies have been proposed. Between 12.6 and 47.6% of children with RLP receive adjuvant interventions, 2,7,8 which are recommended in cases of aggressive disease, when relapse is frequent or there is distal airway compromise. 5 Interferon and cidofovir are the most common adjuvant drugs currently used; however, as well as other adjuvant drug strategies already utilized, such as photodynamic therapy, indole-3-carbinol, cimetidine, acyclovir, retinoids, ribavirin, and mumps vaccine, they have shown controversial results and none have gained wide acceptance so far.…”

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confidence: 99%