British Thoracic Society guideline for non-CFbronchiectasis

Pasteur, Mark C.; Bilton, Diana; Hill, Adam T.

doi:10.1136/thx.2010.136119

Cited by 859 publications

(448 citation statements)

References 492 publications

(680 reference statements)

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“…Other inflammatory processes may be associated with local and systemic inflammation that leads to changes in the architecture of bronchial airways. However, a clear trigger is not identified in up to 30%‐53% of patients 1. Regardless of the cause, when mucociliary clearance is impaired, mucous is retained in the airways 15.…”

Section: Pathophysiology Of Ncfbmentioning

confidence: 99%

“…Bronchiectasis is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections 1. The changes in the bronchial walls may be due to chronic inflammation secondary to recurrent or chronic infections in the lung, but often the exact cause is not identified 1.…”

Section: Introductionmentioning

confidence: 99%

“…The changes in the bronchial walls may be due to chronic inflammation secondary to recurrent or chronic infections in the lung, but often the exact cause is not identified 1. Symptoms vary from intermittent episodes of respiratory infections with excessive mucus production to chronic symptoms with persistent daily expectoration of purulent sputum 1.…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms vary from intermittent episodes of respiratory infections with excessive mucus production to chronic symptoms with persistent daily expectoration of purulent sputum 1. In patients without cystic fibrosis, the condition is known as non‐cystic fibrosis bronchiectasis (NCFB) 1, 2, 3. Although NCFB was once a very uncommon diagnosis, in the last two decades its prevalence has been increasing, making it more likely that primary care clinicians will encounter these patients in their practice.…”

Section: Introductionmentioning

confidence: 99%

“…HRCT, which is able to acquire 1‐mm thick images of the lung at 10‐mm intervals, is considered the gold standard for radiographic diagnosis of NCFB 1, 2. Other modalities of CT using different imaging algorithms have been frequently used to effectively diagnose bronchiectasis 12, 14.…”

Section: Introductionmentioning

confidence: 99%

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Suspecting non-cystic fibrosis bronchiectasis: What the busy primary care clinician needs to know

et al. 2017

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SummaryAimsNon‐cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. In the last several decades, its prevalence has increased, making it likely to be encountered in the primary care setting. The aim was to review the clinical presentation and diagnosis of NCFB, with an emphasis on the role of computed tomography (CT).MethodsFor this review, trials and reports were identified from PubMed/Medline and ClinicalTrials.gov from the US NIH and the Cochrane Register of Controlled Trials. The search used keywords: bronchiectasis, non‐cystic fibrosis bronchiectasis, chronic pulmonary infection and computed tomography. No date/language restrictions were used.ResultsNon‐cystic fibrosis bronchiectasis often coexists with other respiratory conditions, such as chronic obstructive pulmonary disease. The prevalence of NCFB is increasing, particularly in women and older individuals, possibly as a result of increased physician awareness and widespread use of CT, which is the gold standard for the diagnosis of NCFB. CT can assist in identifying an underlying cause of NCFB and determining the extent and severity of the disease.DiscussionNon‐cystic fibrosis bronchiectasis should be suspected in the primary care setting in patients with chronic cough, purulent sputum and frequent respiratory infections that tend to resolve slowly or partially. Early diagnosis and determination of the extent and severity of the disease by CT and other tests are critical to establish therapy to improve quality of life and potentially slow progressive decline of lung function in patients with NCFB .

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Section: Pathophysiology Of Ncfbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%