The main aim of this thesis is to gain new knowledge about the lithospherical structure and tectonics of the Carpathian-Pannonian Basin region. We applied three different methods: 1D automatic modelling, 2D integrated geophysical modelling and 3D inversion to achieve this goal. These methods are similar concerning the used databases but differ by used processing and interpretation. At first we apply 1D automatic modelling to get a very first overview of the studied region. Secondly, we apply 2D integrated modelling of the lithosphere which combines the interpretation of surface heat flow, geoid, gravity, and topography data in the Carpathian-Pannonian Basin region and surrounding areas. This approach is able to constrain the complicated lithospheric structures of the studied region better than interpreting each data set on its own. We present four 2D integrated models of the lithosphere in the Carpathian-Pannonian Basin region and surrounding areas. Finally, based on the 3D Inversion algorithm, we present the geophysical models of the lithosphere in the Carpathian-Pannonian region. The algorithm returns the density structure of the lithosphere from joint inversion of free air gravity, geoid and topography data based on a Bayesian approach. The models are based on different input data sets and constrained by different a priori data. Based on our modelling we cannot confirm the extreme thinning (less than 70 km) of the Pannonian Basin lithosphere proposed by other authors. On the other hand, the results show the increasing trend of the lithospherical thickness of the Carpathian Arc from the Western Carpathians toward the Eastern Carpathians which confirms the previous theories about the propagation of subduction process. We got some controversial results in the area of the Southern Carpathians. The results based on 3D inversion show extremely thin lithosphere in the area; on the other hand, the results based on 2D integrated modelling do not support such thinning. However both methods indicate that it is probable that the Moesian Platform is bend and underthrusted underneath the Southern Carpathians. The southeastern edge of the Pannonian Basin based on 3D inversion shows unexpected and surprisingly thin lithosphere. Since the area is quite large, we could exclude an effect of flexure, therefore this area might be potentially interesting for further investigation.