Broad bandwidth of perceptual learning in the visual system of adults with anisometropic amblyopia

Huang, Chang-Bing; Zhou, Yifeng; Lü, Zhong-Lin

doi:10.1073/pnas.0800824105

Cited by 185 publications

(251 citation statements)

References 43 publications

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“…This predicts that visual stimulation would be more effective at broadly strengthening visual responses in dark-exposed amblyopes than in binocular subjects. Interestingly, the gains in visual acuity promoted by active visual discrimination are less input-specific in human amblyopes than in nonamblyopic subjects (Huang et al 2008;Astle et al 2010). Importantly, dark-exposure enhances the experience-dependent recovery from Cold Spring Harbor Laboratory Press on May 12, 2018 -Published by learnmem.cshlp.org Downloaded from amblyopia in kittens, demonstrating that this paradigm can be successfully applied to animals with a columnar distribution of ocular dominance (Duffy and Mitchell 2013).…”

Section: The Visual Cortex Of Dark-exposed Amblyopes Is Hyperplasticmentioning

confidence: 82%

Repetitive visual stimulation enhances recovery from severe amblyopia

2013

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Severe amblyopia, characterized by a significant reduction in visual acuity through the affected eye, is highly resistant to reversal in adulthood. We have previously shown that synaptic plasticity can be reactivated in the adult rat visual cortex by dark exposure, and the reactivated plasticity can be harnessed to promote the recovery from severe amblyopia. Here we show that deprived-eye visually evoked responses are rapidly strengthened in dark-exposed amblyopes by passive viewing of repetitive visual stimuli. Surprisingly, passive visual stimulation rapidly enhanced visually evoked responses to novel stimuli and enhanced the recovery from severe amblyopia driven by performance of active visual discriminations. Thus a series of simple, noninvasive manipulations of visual experience can be used in combination to significantly guide the recovery of visual response strength, selectivity, and spatial acuity in adult amblyopes.

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Section: The Visual Cortex Of Dark-exposed Amblyopes Is Hyperplasticmentioning

confidence: 82%

Repetitive visual stimulation enhances recovery from severe amblyopia

2013

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“…Ultimately, the tradeoff between the specificity and generalizability of visual perceptual learning is determined by the strength of stimulus selectivity of neurons in primary visual cortex. The significant reduction of visual response strength and selectivity induced by chronic monocular deprivation (Montey and Quinlan 2011) predicted that perceptual learning through the amblyopic eye would be less stimulus-specific, as has been demonstrated in humans (Huang et al 2008). The stimulus selectivity of visual perceptual learning likely reflects the input specificity of learninginduced synaptic modifications.…”

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confidence: 99%

Optimization of visual training for full recovery from severe amblyopia in adults

2016

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The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.

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“…More plasticity and wider generalization in the amblyopic visual system has been found, thus providing a strong empirical and theoretical basis for perceptual learning as a potential treatment for amblyopia. Furthermore, the GABAergic anterior paired lateral neurons function by inhibitory regulation to facilitate olfactory reversal learning by suppressing initial memory in Drosophila [8,9] .…”

Section: Neural Circuit Research In Emotion and Memorymentioning

confidence: 99%

Grand Research Plan for Neural Circuits of Emotion and Memory — Current status of neural circuit studies in China

2013

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During recent years, major advances have been made in neuroscience, i.e., asynchronous release, threedimensional structural data sets, saliency maps, magnesium in brain research, and new functional roles of long non-coding RNAs. Especially, the development of optogenetic technology provides access to important information about relevant neural circuits by allowing the activation of specific neurons in awake mammals and directly observing the resulting behavior. The Grand Research Plan for Neural Circuits of Emotion and Memory was launched by the National Natural Science Foundation of China. It takes emotion and memory as its main objects, making the best use of cutting-edge technologies from medical science, life science and information science. In this paper, we outline the current status of neural circuit studies in China and the technologies and methodologies being applied, as well as studies related to the impairments of emotion and memory. In this phase, we are making efforts to repair the current deficiencies by making adjustments, mainly involving four aspects of core scientific issues to investigate these circuits at multiple levels. Five research directions have been taken to solve important scientific problems while the Grand Research Plan is implemented. Future research into this area will be multimodal, incorporating a range of methods and sciences into each project. Addressing these issues will ensure a bright future, major discoveries, and a higher level of treatment for all affected by debilitating brain illnesses.

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Broad bandwidth of perceptual learning in the visual system of adults with anisometropic amblyopia

Cited by 185 publications

References 43 publications

Repetitive visual stimulation enhances recovery from severe amblyopia

Repetitive visual stimulation enhances recovery from severe amblyopia

Optimization of visual training for full recovery from severe amblyopia in adults

Grand Research Plan for Neural Circuits of Emotion and Memory — Current status of neural circuit studies in China

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