Broad-Based Screening of Polymer Biodegradability

Reactive immunization elicits catalytic antibodies for polyester hydrolysis

“…1 However, it is generally difficult to engineer a biological system capable of handling nonnatural polymers. 2 Antibodies can be easily designed to bind most organic substances with high affinity and specificity. 3 An antibody capable of high-affinity binding to a transition state of a chemical reaction is by definition a catalyst for this reaction.…”