Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants

Shukla, Vibha; Bhathena, Zarine

doi:10.1155/2016/5823013

Cited by 29 publications

(18 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the extracts showed distinct protein binding ability and may be disrupting QS either by inactivating enzymes responsible for the synthesis of the AIs or by binding to protein receptors of QS signals. [ 73 ]…”

Section: P Lant B Y-products As mentioning

confidence: 99%

Anti-quorum sensing natural compounds

Asfour

2018

J Microsc Ultrastruct

235

109

View full text Add to dashboard Cite

Increasing extent of pathogenic resistance to drugs has encouraged the seeking for new anti-virulence drugs. Many pharmacological and pharmacognostical researches are performed to identify new drugs or discover new structures for the development of novel therapeutic agents in the antibiotic treatments. Although many phytochemicals show prominent antimicrobial activity, their power lies in their anti-virulence properties. Quorum sensing (QS) is a bacterial intercellular communication mechanism, which depends on bacterial cell population density and controls the pathogenesis of many organisms by regulating gene expression, including virulence determinants. QS has become an attractive target for the development of novel anti-infective agents that do not rely on the use of antibiotics. Anti-QS compounds are known to have the ability to prohibit bacterial pathogenicity. Medicinal plants offer an attractive repertoire of phytochemicals with novel microbial disease-controlling potential, due to the spectrum of secondary metabolites present in extracts, which include phenolics, quinones, flavonoids, alkaloids, terpenoids, and polyacetylenes. They have recently received considerable attention as a new source of safe and effective QS inhibitory substances. The objective of this review is to give a brief account of the research reports on the plants and natural compounds with anti-QS potential.

show abstract

Section: P Lant B Y-products As mentioning

confidence: 99%

Anti-quorum sensing natural compounds

Asfour

2018

J Microsc Ultrastruct

235

109

View full text Add to dashboard Cite

show abstract

“…Extracts from Korean indigenous plants also exhibited QSI against C. violaceum and P. aeruginosa bioreporters [166]. Recently, Shukla and coworkers [186] found that tannin-rich crude extracts from six Indian medicinal plants ( Phyllanthus emblica , Terminalia bellirica , Terminalia chebula , P. granatum , Syzygium cumini , and Mangifera indica ) commonly used in Ayurveda showed QQ properties against C. violaceum and S. aureus at sub-inhibitory concentrations. Anti-QS activity was also obtained against S. aureus with methanolic extracts rich in pentacyclic triterpenes (ursene and oleanene derivatives) from the Italian medicinal plant Castanea sativa .…”

Section: Plant-based Strategies To Deal With Unwanted Biofilmsmentioning

confidence: 99%

New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms

et al. 2016

View full text Add to dashboard Cite

Abstract:The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of severity and the persistence of infections are worsened when microorganisms form biofilms. Therefore, efforts are being applied to develop new drugs not as vulnerable as the current ones to bacterial resistance mechanisms, and also able to target bacteria in biofilms. Natural products, especially those obtained from plants, have proven to be outstanding compounds with unique properties, making them perfect candidates for these much-needed therapeutics. This review presents the current knowledge on the potentialities of plant products as antibiotic adjuvants to restore the therapeutic activity of drugs. Further, the difficulties associated with the use of the existing antibiotics in the treatment of biofilm-related infections are described. To counteract the biofilm resistance problems, innovative strategies are suggested based on literature data. Among the proposed strategies, the use of phytochemicals to inhibit or eradicate biofilms is highlighted. An overview on the use of phytochemicals to interfere with bacterial quorum sensing (QS) signaling pathways and underlying phenotypes is provided. The use of phytochemicals as chelating agents and efflux pump inhibitors is also reviewed.

show abstract

“…Further, transcriptional analysis showed that this fraction downregulates the expression of curli genes ( csgB and csgD ) and various motility genes ( fimA, fimH, flhD, motB, qseB , and qseC ) in Escherichia coli . Broad spectrum anti-QS activity of hydrolysable tannin-rich extracts of Indian medicinal plants Phyllanthus emblica, Terminalia bellirica, Terminalia chebula, Punica granatum, Syzygium cumini and Mangifera indica was reported by Shukla and Bhathena [96]. The authors suggest the tannin bioactivity mechanism is mediated by protein precipitation that may disrupt QS by inactivating various enzymes responsible for the autoinducer synthesis or by binding to protein receptors of QS signals.…”

Section: Plant-derived Molecules That Affect Ahl-mediated Qs In Bamentioning

confidence: 98%

Plant-Derived Inhibitors of AHL-Mediated Quorum Sensing in Bacteria: Modes of Action

Deryabin

Галаджиева

Kosyan

et al. 2019

IJMS

112

View full text Add to dashboard Cite

Numerous gram-negative phytopathogenic and zoopathogenic bacteria utilise acylated homoserine lactone (AHL) in communication systems, referred to as quorum sensing (QS), for induction of virulence factors and biofilm development. This phenomenon positions AHL-mediated QS as an attractive target for anti-infective therapy. This review focused on the most significant groups of plant-derived QS inhibitors and well-studied individual compounds for which in silico, in vitro and in vivo studies provide substantial knowledge about their modes of anti-QS activity. The current data about sulfur-containing compounds, monoterpenes and monoterpenoids, phenylpropanoids, benzoic acid derivatives, diarylheptanoids, coumarins, flavonoids and tannins were summarized; their plant sources, anti-QS effects and bioactivity mechanisms have also been summarized and discussed. Three variants of plant-derived molecules anti-QS strategies are proposed: (i) specific, via binding with LuxI-type AHL synthases and/or LuxR-type AHL receptor proteins, which have been shown for terpenes (carvacrol and l-carvone), phenylpropanoids (cinnamaldehyde and eugenol), flavonoid quercetin and ellagitannins; (ii) non-specific, by affecting the QS-related intracellular regulatory pathways by lowering regulatory small RNA expression (sulphur-containing compounds ajoene and iberin) or c-di-GMP metabolism reduction (coumarin); and (iii) indirect, via alteration of metabolic pathways involved in QS-dependent processes (vanillic acid and curcumin).

show abstract

Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants

Cited by 29 publications

References 42 publications

Anti-quorum sensing natural compounds

Anti-quorum sensing natural compounds

New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms

Plant-Derived Inhibitors of AHL-Mediated Quorum Sensing in Bacteria: Modes of Action

Contact Info

Product

Resources

About