Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation

Abstract

<p>Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms. Combination of nanoparticles and organic photosensitizers offer...</p>

Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal

“…Also, an important dark toxicity of the polymers (∼6 log 10 CFU/ml reduction) was observed, indicating that the polymeric matrix is also playing an important role, probably due to the presence of the ammonium groups that can interact efficiently with the external wall of the bacterium cell (57). This activity is comparable to that reported for methylene blue encapsulated in porous silica nanoparticles (58) and for chitosan used as a carrier of Toluidine blue O (59) that also induced a reduction of 8 log 10 CFU/ml, and for the aforementioned system involving indocyanine green loaded in superparamagnetic iron oxide nanoparticles, which induced a reduction of 12 log 10 CFU/ml (53). Nevertheless, in these cases, the activity of the materials in the dark is negligible or very low.…”

“…Some recent examples using photosensitizing materials are shown in Table 3 . Interestingly, Bilici et al ( 53 ) reported a remarkable activity of indocyanine green loaded in superparamagnetic iron oxide nanoparticles. However, they combined photodynamic therapy with photothermal therapy to trigger antibacterial phototoxicity, which cannot be comparable with our system or any of the other studies presented in Table 3 .…”

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

“…Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) had been also used for antimicrobial materials. Indeed, they are well-known as effective PhotoThermal Therapy (PTT) agents that could be associated with PS in order to reach combined PTT-PDT systems [116] . In this line, Bilici et al investigated the bactericidal effect of indocyanine green (ICG, 159, Fig.…”

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

“…6,21,[24][25][26] PTT offers a broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria without inducing marked drug resistance. 27 Considering all these benefits, a variety of photothermal antibacterial agents have been developed to boost the development of PTT, such as gold-based nanomaterials, 28,29 copper-based chalcogenide nanomaterials, 30 carbon-based nanomaterials, 31 polymer nanoparticles, [32][33][34] and black phosphorus. 35 Among them, copper-based materials have attracted much attention due to their low cost and stable photothermal conversion performance.…”