Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial

Kenyon, Sara; Taylor, David; Tarnow-Mordi, W.

doi:10.1016/s0140-6736(00)04233-1

Cited by 570 publications

(184 citation statements)

References 19 publications

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“…At present, benefits of the use of prophylactic antibiotics are clear. It has been observed a prolongation of the latency period, a decrease in diagnoses of chorioamnionitis, neonatal respiratory distress and sepsis when prophylactic antibiotics are used [15][16][17]. In our experience, the ORACLE II study provided consistency in antibiotic treatments for PPROM, subjected to some variability until 2003 [18].…”

Section: Discussionmentioning

confidence: 84%

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes

González-Mesa

Herrera

Urgal

et al. 2012

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 84%

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes

González-Mesa

Herrera

Urgal

et al. 2012

Arch Gynecol Obstet

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“…However, no consensus exists regarding the antibiotic to be used, apart from the avoidance of the amoxicillin-clavulanic acid combination due to the increased risk of necrotizing enterocolitis associated with it [32]. In case of pPROM, antibiotics reduce neonatal infections, surfactant use and oxygen requirement [33].…”

Section: Modulators Of Inflammation/infectionmentioning

confidence: 99%

“…Antibiotic use in the context of pPROM was associated with a significant reduction in IVH (RR 0.67; 95% CI 0.49-0.91) and in abnormal cerebral ultrasound results prior to discharge (RR 0.81; 95% CI 0.68-0.98) [32]. The ORACLE I study was designed as a long-term follow-up of infants receiving prenatal antibiotics for pPROM and reported no demonstrable effect on neurological outcome compared to the absence of treatment [38].…”

Section: Modulators Of Inflammation/infectionmentioning

confidence: 99%

Impact of Common Treatments Given in the Perinatal Period on the Developing Brain

et al. 2014

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Background: Over the last decades, considerable progress has been made in the perinatal management of high-risk preterm neonates, changing the landscape of pathological conditions associated with neurological impairments. Major focal destructive lesions are now less common, and the predominant neuropathological lesion is diffuse white-matter damage in the most immature infants. Similarly, over the last few years, we have observed a trend towards a decrease in neurological impairment in the absence of treatments specifically aimed at neuroprotection. Objectives: We examined whether recent changes in treatment strategies in perinatal care during the perinatal period could have had an indirect beneficial impact on the occurrence of brain lesions and their consequences. Methods: Thus, we reviewed the effects of the most common treatments administered during the perinatal period to the mother or to very preterm infants on brain damage and neurocognitive follow-up. Results: Antenatal steroids and exogenous surfactant are the two main treatments capable of leading to neuroprotection in very preterm infants. Randomized controlled trials are currently investigating the effects of inhaled nitric oxide and erythropoietin, while antenatal magnesium sulphate and caffeine are also likely to provide some neuroprotection, but this needs to be further investigated. Finally, other common treatments against pain, haemodynamic failure and patent ductus arteriosus have conflicting or no effects on the developing brain. Conclusion: While specific neuroprotective drugs are still awaited, recent advances in perinatal care have been associated with an unexpected but significant decrease in the incidence of both severe brain lesions and neurological impairment.

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“…Die routinemäßige Anwendung von Antibiotika bei erhaltener Fruchtblase aus dem alleinigen Grund der Prävention einer Frühgeburt ist dagegen nicht indiziert [11,12,13].…”

Section: Additive Maßnahmenunclassified

Tokolyse bei vorzeitiger Wehentätigkeit

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Vetter

2007

Gynäkologe

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Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial

Cited by 570 publications

References 19 publications

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes

Impact of Common Treatments Given in the Perinatal Period on the Developing Brain

Tokolyse bei vorzeitiger Wehentätigkeit

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