Broad spectrum antimicrobial PDMS-based biomaterial for catheter fabrication

Abstract

Background In addition to the widespread use of antibiotics in healthcare settings, the current COVID-19 pandemic has escalated the emergence of antibiotic resistance. Nosocomial infections among hospitalized patients is a leading site for such resistant microbial colonization due to prolonged use of invasive devices and antibiotics in therapies. Invasive medical devices, especially catheters, are prone to infections that could accelerate the development of resistant microbes. Often, catheters - particularly urinary catheters - are prone to high infection rates. Antibiotic-coated catheters can reduce infection rates and although commercially available, are limited in efficacy and choices. Methods Herein, a novel and facile method to fabricate PMDS-based biomaterial for the development of antimicrobial eluting catheters is presented. Silicone based organic polymer polydimethylsiloxane (PDMS) was used to prepare a biomaterial containing novel polymeric imidazolium antimicrobial compound. Results It was found that the PDMS-based biomaterials could eradicate microbial colonization even after 60 days in culture with continuous microbial challenge, be recycled over multiple uses, stored at room temperature for long-term usage and importantly is biocompatible. Conclusion The PDMS-based biomaterial displayed biocidal functionality on microbes of clinical origin, which form major threats in hospital acquired infections. Graphical Abstract

Prevention of medical device infections via multi‐action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces

“…Previous studies have reported bactericidal or bacteria resistant approaches to reduce the microbial burden on medical devices. These strategies include impregnation of antimicrobial agents, such as silver, zinc 11,12 in siliconebased polymers, 13,14 anti-fouling mechanisms (e.g., SLIPs and zwitterions), [14][15][16][17] antibiotic and antimicrobial coated/impregnated catheters (chlorhexidine [CHXD], silver sulfadiazine, rifampicin, auranofin, etc. ), [18][19][20][21] and nitric oxide (NO)-releasing therapeutic approaches.…”

Development and Characterization of Lactobacillus rhamnosus-Containing Bioprints for Application to Catheter-Associated Urinary Tract Infections

“…Furthermore, the L. rhamnosus-containing biomaterial had a greater tensile strength than the ∼0.5 MPa recently reported for an antimicrobial PDMS-based biomaterial for urinary catheter fabrication . Depending on future in vivo evaluation, composite fillers could be investigated to enhance the tensile strength of the biomaterial.…”

“…53 Furthermore, the L. rhamnosuscontaining biomaterial had a greater tensile strength than the ∼0.5 MPa recently reported for an antimicrobial PDMS-based biomaterial for urinary catheter fabrication. 54 Depending on future in vivo evaluation, composite fillers could be investigated to enhance the tensile strength of the biomaterial. Data from mechanical integrity testing of the L. rhamnosus-containing constructs showed minimal degradation compared to blank scaffolds as well as minimal increase in volume and outer diameter (Figure 2), suggesting the feasibility of this biomaterial for urinary catheters.…”

A high-throughput integrated biofilm-on-a-chip platform for the investigation of combinatory physicochemical responses to chemical and fluid shear stress

“…The choice of PDMS is advantageous as the device can be used for investigating silicon coating materials for a broad range of implantation applications. PDMS is widely used as a coating material in neural and cochlear implants [40], and PDMS-based biomaterials are used for catheter fabrication with antimicrobial properties [52]. Additionally, using PDMS for this device guarantees its universality since the stiffness is mechanically tunable by several orders of magnitude.…”