Broadband homodecoupled heteronuclear multiple bond correlation spectroscopy

Boosting the Resolution of 1H NMR Spectra by Homonuclear Broadband Decoupling

“…Proton-proton broadband decoupling has so far been less frequently used due to its huge loss in sensitivity and the often quite sophisticated processing schemes. The range of 2D spectra that have been decoupled in one or both dimensions encompasses TOCSY, [15,18] NOESY, [22] HMBC [23] and HSQC [24,25] experiments. The introduction of decoupling during acquisition comes along with a big boost in sensitivity per time, and maybe even more advantageously, it completely eliminates any special processing.…”

Homonuclear decoupling by projection reconstruction

“…Even simple methods to remove strong coupling artifacts are available in the meantime . The approach has been extended to heteronuclear multiple bond correlation (HMBC) experiments with the so‐called tilt‐HMBC, which essentially is a pseudo‐3D HMBC‐ J ‐resolved experiment that is processed in a way to obtain a homodecoupled 2D‐HMBC spectrum . The multiplet tilt has also been used in high‐resolution heteronuclear single bond correlation (HR‐HSBC) experiments for the accurate measurement of 1 T CH couplings .…”

“…[33] The approach has been extended to heteronuclear multiple bond correlation (HMBC) experiments with the so-called tilt-HMBC, which essentially is a pseudo-3D HMBC-J-resolved experiment that is processed in a way to obtain a homodecoupled 2D-HMBC spectrum. [34] The multiplet tilt has also been used in high-resolution heteronuclear single bond correlation (HR-HSBC) experiments for the accurate measurement of 1 T CH couplings. [35] In the latter case, simple projection along a tilted spectrum unfortunately is not sufficient, because the multiplet in the indirect dimension is also modulated by the a priori unknown carbon chemical shifts.…”

Enantiodifferentiation through Frequency‐Selective Pure‐Shift 1H Nuclear Magnetic Resonance Spectroscopy

“…The projection along the detected dimension of a J-resolved experiment requires a 2D-acquisition mode, and, therefore, the SNR reduction is proportional to the number of acquired increments. [10] The use of multiple slice selection through sequential or simultaneous slice excitation [14] can improve the relative SNR, but the sensitivity levels are still far from those obtained in the conventional 1 H NMR spectra. [8] Recently, single-shot ZS methods have been proposed for the fast acquisition of broadband homodecoupled 1D 1 H NMR spectra, but they also experience considerable sensitivity losses because of 13 C editing [9] or spatial selection.…”

“…[8] Recently, single-shot ZS methods have been proposed for the fast acquisition of broadband homodecoupled 1D 1 H NMR spectra, but they also experience considerable sensitivity losses because of 13 C editing [9] or spatial selection. [10] The use of multiple slice selection through sequential or simultaneous slice excitation [14] can improve the relative SNR, but the sensitivity levels are still far from those obtained in the conventional 1 H NMR spectra. In terms of SNR per time unit, a single selective method is more than one order of magnitude more sensitive than the aforementioned pure-shift methods, which ensures that, for small molecules, recording series of individual selective 1D experiments can be faster and more effective than running a broadband experiment.…”