Broadening the scope of Image-Guided Radiotherapy (IGRT)

Greco, Carlo; Ling, C. Clifton

doi:10.1080/02841860802241956

Cited by 23 publications

(24 citation statements)

References 79 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some define it very broadly i.e., use of imaging for detection and diagnosis; delineation of target volumes and organs-at-risk (OARs); determining biological attributes; dose distribution design; dose delivery verification and assurance; and deciphering treatment response. [1] This is more aptly termed image-based radiation therapy rather than IGRT. A more focussed and accepted definition of IGRT is ‘use of frequent imaging within the radiation treatment room, with decisions based on imaging to improve precision of radiation therapy delivery i.e., process of in-room imaging guiding radiation delivery’.…”

Section: Definition Of Igrtmentioning

confidence: 99%

See 1 more Smart Citation

Image-guided radiation therapy: Physician′s perspectives

Gupta

Narayan

2012

J Med Phys

View full text Add to dashboard Cite

The evolution of radiotherapy has been ontogenetically linked to medical imaging. Over the years, major technological innovations have resulted in substantial improvements in radiotherapy planning, delivery, and verification. The increasing use of computed tomography imaging for target volume delineation coupled with availability of computer-controlled treatment planning and delivery systems have progressively led to conformation of radiation dose to the target tissues while sparing surrounding normal tissues. Recent advances in imaging technology coupled with improved treatment delivery allow near-simultaneous soft-tissue localization of tumor and repositioning of patient. The integration of various imaging modalities within the treatment room for guiding radiation delivery has vastly improved the management of geometric uncertainties in contemporary radiotherapy practice ushering in the paradigm of image-guided radiation therapy (IGRT). Image-guidance should be considered a necessary and natural corollary to high-precision radiotherapy that was long overdue. Image-guided radiation therapy not only provides accurate information on patient and tumor position on a quantitative scale, it also gives an opportunity to verify consistency of planned and actual treatment geometry including adaptation to daily variations resulting in improved dose delivery. The two main concerns with IGRT are resource-intensive nature of delivery and increasing dose from additional imaging. However, increasing the precision and accuracy of radiation delivery through IGRT is likely to reduce toxicity with potential for dose escalation and improved tumor control resulting in favourable therapeutic index. The radiation oncology community needs to leverage this technology to generate high-quality evidence to support widespread adoption of IGRT in contemporary radiotherapy practice.

show abstract

Section: Definition Of Igrtmentioning

confidence: 99%

“…[1] The radiation oncology community has a strong tradition of using imaging for diagnosis, management, and prognosis in cancer. [2] Imaging has been used for cancer detection, staging, target volume delineation, treatment planning, delivery verification, and response assessment.…”

Section: Introductionmentioning

confidence: 99%

Image-guided radiation therapy: Physician′s perspectives

Gupta

Narayan

2012

J Med Phys

View full text Add to dashboard Cite

show abstract

“…Some studies indicate (26)(27) that pneumonia was related to V 5 , V 10 , V 20 , and V 30 . This study showed that the left lung and total lungs V 5 , V 10 , V 20 , and V 30 in the DA plan were lower than the primary CT plan with a statistical significance. It explained that the adaptive re-planning could decrease doses to lungs and other normal tissues.…”

Section: Discussionmentioning

confidence: 84%

“…For this reason, the patients anatomic structural changes should be known as well as the dose distribution and modification should be estimated timely for the fractional radiotherapy. Re-planning on-board has become an important work for a precise radiotherapy (20)(21)(22). Our study used KV CBCT and planning CT image information, re-delineated contours by deformable registration software, and transplanted it to the planning CT images for designing a adaptive plan and calculated the accumulation of fractional dose, and compared with the conventional static radiotherapy plan.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Anatomic Changes and Dosimetric Consequences in Adaptive CRT of Non-Small-Cell Lung Cancer Using Deformable CT and CBCT Image Registration

Hou

et al. 2014

Technol Cancer Res Treat

View full text Add to dashboard Cite

The aim of this study is to evaluate anatomic lung tumor changes and dosimetric consequences utilizing the deformable daily kilovolt (KV) cone-beam computer tomography (CBCT) image registration. Five patients diagnosed with NSCLC were treated with three-dimensional conformal radiotherapy (3D CRT) and 10 daily KV CBCT image sets were acquired for each patient. Each CBCT image and plan CT were imported into the deformable image registration (DIR) system. The plan CT image was deformed by the DIR system and a new contour on CBCT was obtained by using the auto-contouring function of the DIR. These contours were individually marked as CBCT f1, CBCT f2,…, and CBCT f10, and imported into a treatment planning system (TPS). The daily CBCT plan was individually generated with the same planning criteria based on new contours. These plans were individually marked as CBCTp1, CBCTp2,…, and CBCTp10, followed by generating a dose accumulation plan (DA plan) in original pCT image contour sets by adding all CBCT plans using Varian Eclipse TPS. The maximum, minimum and mean doses to the plan target volume (PTV) in the 5 DA plans were the same with the CT plans. However, the volume of radiation 5, 10, 20, 30, and 50 Gy of the total lungs in DA plans were less than those of the CT plans. The maximum dose of the spinal cord in the DA plans were average 27.96% less than the CT plans. The mean dose for the left, right, and total lungs in the DA plans were reduced by 13.80%, 23.65%, and 12.96%, respectively. The adaptive 3D CRT based on the deformable registration can reduce the dose to the lung and the spinal cord with the same PTV dose coverage. Moreover, it provides a method for further adaptive radiotherapy exploration.

show abstract

“…Uma combinação de diferentes aberturas de lâminas, em momentos sequencias, seja de forma dinâmica ou estática, calculada por um software específico produz um feixe de radiação heterogêneo, capaz de direcionar a maior dose para uma determinada estrutura, definida como alvo e uma menor dose de radiação para outras áreas definidas, como tecido peritumoral. 53,59 Figura (9): Na parte superior dessa figura, evidencia-se a diferença nas isodoses de radiação, quando se utilizam as técnicas RT-3D e IMRT, respectivamente. Na parte inferior têm-se um esquema representativo da radioterapia com técnica IMRT.…”

Section: Cisplatina (Cddp)unclassified

Avaliação de diferentes formas de delineamento da medula óssea e correlação com toxicidade hematológica em pacientes com câncer de canal anal submetidos à quimiorradioterapia

Guimarães¹

View full text Add to dashboard Cite

Agradeço, em primeiro lugar, à minha orientadora, Prof a. Dr a. Heloisa de Andrade Carvalho, por todo o conhecimento transmitido, e por toda a confiança, que vem depositando em mim, desde a residência médica no HC-FMUSP. Ao longo dessa longa jornada, sempre se mostrou intelectualmente estimulante, paciente, generosa e persistente, além de todas as outras qualidades que se procura num orientador. Ajudando nas escolhas, respeitando o meu tempo, e, sempre apoiando as minhas ações e decisões que culminaram neste estudo.Como ensinou Leonard Mlodinow: "o orientador certo é importante num curso de doutorado, não só por ser necessário se dar bem com seu mentor, mas, também, porque o caminho pode ser pedregoso se os interesses não estiverem alinhados". Dr a. Heloisa, meu, verdadeiro, muito obrigado! Agradeço, também, à minha co-orientadora, Prof a. Dr a. Karina de Cássia Braga Ribeiro por toda ajuda, paciência, disponibilidade e direção, nos meus telefonemas intermináveis, na análise de dados, nessa parceria nova, que já nasceu consolidada. Muito obrigado! Esta tese, fundamentalmente, apoia-se na ajuda e atenção de seus colaboradores:

show abstract

Broadening the scope of Image-Guided Radiotherapy (IGRT)

Cited by 23 publications

References 79 publications

Image-guided radiation therapy: Physician′s perspectives

Image-guided radiation therapy: Physician′s perspectives

A Study of the Anatomic Changes and Dosimetric Consequences in Adaptive CRT of Non-Small-Cell Lung Cancer Using Deformable CT and CBCT Image Registration

Avaliação de diferentes formas de delineamento da medula óssea e correlação com toxicidade hematológica em pacientes com câncer de canal anal submetidos à quimiorradioterapia

Contact Info

Product

Resources

About