Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen
Ann Fernando,
Amanda Sparkes,
Esther I. Matus
et al.
Abstract:Design strategies
that lead to a more focused in vivo
delivery
of functionalized nanoparticles (NPs) and their cargo can potentially
maximize their therapeutic efficiency while reducing systemic effects,
broadening their clinical applications. Here, we report the development
of a noncovalent labeling approach where immunoglobulin G (IgG)-decorated
NPs can be directed to a cancer cell using a simple, linear bispecific
protein adaptor, termed MFE23-ZZ. MFE23-ZZ was created by fusing a
single-chain fragment varia… Show more
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