Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside

Amjad, Ali Imran; Parikh, Rahul Atul; Appleman, Leonard Joseph; Hahm, Eun‐Ryeong; Singh, Khushboo; Singh, Shivendra V.

doi:10.1007/s40495-015-0034-x

Cited by 60 publications

(42 citation statements)

References 61 publications

(72 reference statements)

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“…Oxidative stress is a well established cause in the initiation and progression of cancers [46]. Anti-oxidant and anti-inflammatory compounds like cyclooxygenase-2 inhibitors, natural compounds like silibinin and other flavonoids are currently being investigated as potential CaP treatments [47–49]. OSL has been investigated for its chemopreventive properties in dimethyl-benzanthracene (DMBA)-induced oral cancer [50], and also functions as a radio-protectant for bone marrow cells [51–53].…”

Section: Introductionmentioning

confidence: 99%

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer

Singhal

Jain

Singhal³

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Prostate cancer (CaP) is often androgen-sensitive malignancy and regresses upon inhibition of androgen signaling. However, CaP, nearly always develops androgen resistance and progresses to aggressive and lethal androgen-independent CaP, which lacks satisfactory therapy. For metastatic CaP, patients are often treated with Taxotere (docetaxel), a cytoskeleton-targeted chemotherapy drug, that provides transient palliative benefit but to which patients rapidly develop drug-resistance. Combination chemotherapy may be used instead, but is more toxic and adds little clinically relevant benefit over docetaxel. Therefore, novel strategies to enhance docetaxel efficacy are needed to effectively treat patients with metastatic CaP. The mercapturic acid pathway, which metabolizes genotoxic and pro-apoptotic toxins, is over-expressed in CaP and plays an important role in carcinogenesis, metastasis and therapy-resistance of CaP. Vicenin-2, a flavonoid derived from Tulsi (holy basil) as an active compound, inhibits the growth of CaP and increases the anti-tumor activity of docetaxel in-vitro and in-vivo. Taken together, the combination of vicenin-2 and docetaxel could be highly effective in the treatment of advanced and metastatic CaP due to their multi-targeting anti-tumor potential.

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Section: Introductionmentioning

confidence: 99%

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer

Singhal

Jain

Singhal³

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…Many studies have examined the anti-cancer effects of sulforaphane in control of tumorigenesis or progression of lung cancer [1] , breast cancer [2] , prostate cancer [3] and digestive system neoplasms [4][5][6] . However, the effect of sulforaphane on lung cancer metastasis, which limits the lifespan of lung cancer patients, has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways

et al. 2016

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Sulforaphane is a common antioxidant selectively abundant in cruciferous plants, which exhibits effective anti-cancer actions in control of tumorigenesis or progression of various cancers. A recent study has shown that sulforaphane attenuates the EGFR signaling pathway in non-small cell lung cancer (NSCLC), suggesting its potential anti-metastatic effects. In this study we assessed the involvement of sulforaphane and miR-616-5p in epithelial-mesenchymal transition (EMT) and NSCLC metastasis. Sulforaphane suppressed the cell proliferation in human NSCLC cell lines H1299, 95C and 95D with IC 50 values of 9.52±1.23, 9.04±1.90 and 17.35±2.03 μmol/L, respectively. At low concentrations (1-5 μmol/L), sulforaphane dose-dependently inhibited the migration and invasion of 95D and H1299 cells with relatively high metastatic potential. The anti-metastatic action of sulforaphane was confirmed in 95D and H1299 cell xenografts in vivo. In fresh NSCLC tissue samples from 179 patients, miR-616-5p levels were upregulated in late-stage NSCLCs, and strongly correlated with risk of NSCLC recurrence and metastasis. Consistent with the clinic observation, miR-616-5p levels in the 3 NSCLC cell lines were correlated with their metastatic ability, and were decreased by sulforaphane treatment. Silencing miR-616-5p markedly suppressed the migration and invasion of 95D cells in vitro and NSCLC metastasis in vivo. Further studies revealed that miR-616-5p directly targeted GSK3β and decreased its expression, whereas sulforaphane decreased miR-616-5p levels by histone modification, and followed by inactivation of the GSK3β/β-catenin signaling pathway and inhibition of EMT, which was characterized by loss of epithelial markers and acquisition of a mesenchymal phenotype in NSCLC cells. Our findings suggest that sulforaphane is a potential adjuvant chemotherapeutic agent for the prevention of NSCLC recurrence and metastasis, and miR-616-5p can be clinically utilized as a biomarker or therapeutic target to inhibit metastasis.

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“…Its anticancer potency and the underlying mechanisms have been studied extensively using various cell cultures and experimental models [9].…”

Section: Cancer Treatmentmentioning

confidence: 99%

Nutraceuticals: The New Generation Therapeutics

Ganapathy¹,

Bhunia²

2015

Adv Tech Biol Med

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Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside

Cited by 60 publications

References 61 publications

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer

Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways

Nutraceuticals: The New Generation Therapeutics

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