Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial

Abstract

Background/Objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients. Subjects/Methods: A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n ¼ 27), 5 g/d BSP (n ¼ 29) or placebo (n ¼ 25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment. Results: In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n ¼ 21), 5 g/d (n ¼ 22) and placebo (n ¼ 20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P ¼ 0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P ¼ 0.03 for treatment effect), OSI (P ¼ 0.001 for treatment effect) and significant increase in TAC (P ¼ 0.001 for treatment effect). No effects were found on TOS. Conclusion: BSP had favorable effects on oxidative stress status in type 2 diabetes patients.

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“…The results agreed with Bahadoran, et al [19] who mentioned the occurrence of a significant decrease in the level of malondialdehyde, low-density lipoproteins, and the index of oxidative stress, whereas an increase in the total antioxidant capacity in the serum blood of patients with diabetes who ate 5 gm dried broccoli, 10 gm daily for 4 weeks (number 29, 27, respectively), and that by patients who did not eat broccoli (number = 25).…”

Dysregulation of Nrf2 Signaling in Diabetes: An Opportunity for a Multitarget Approach

“…SFN has been shown to have similar effects in diabetic nephropathy. 3 months of SFN treatment attenuated loss of kidney function, fibrosis and TGF-β expression, reduced inflammation and TNFα, and oxidative stress in the kidneys of diabetic mice [47,48] [49].…”

The role of phytochemicals in modulating intrinsic human cellular defence processes

“…197 An earlier 2004 study by another group examined markers of metabolic syndrome but did not quantify SFN in a fresh broccoli sprout intervention. 37 A dose of 10 g of a 0.4% SFN-yielding broccoli sprout powder demonstrated beneficial effects in several cardio-metabolic biomarkers.…”

“…711 , this may be an avenue for further investigation of the properties of SFN, especially given that SFN has already been shown to have positive effects in patients with type 2 diabetes. 197,432 ACSM2A is also associated with enhanced glycine conjugation in detoxification of xenobiotics like benzoate, ibuprofen and aspirin. 712 The possible role of SFN in this context deserves further investigation.…”

“…37,38,41,197,245,318,[383][384][385][397][398][399]412,[424][425][426][427][428][429][430][431][432] These materials include mature broccoli vegetable (raw and cooked), fresh broccoli sprouts, MYR-inactive broccoli extract beverage, MYR-inactive powdered broccoli sprout extract (BSE), MYR-active broccoli sprout powder and capsules made from MYRinactive broccoli extract. Several of the studies 38,397,398,430 confirm the necessity for MYR in optimising SFN Yield, citing cooking and extraction as being the primary processes leading to loss of activity.…”