Bromadiolone Induced Oxidative Stress and Cytological Damage in Layer Birds

Sodhi, Simrinder Singh; Brar, R. S.; Banga, H. S.

doi:10.23953/cloud.ijavst.272

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, ¼LD 50 of COM significantly decreased SOD activity in liver of all studied rat species Gerbillus Gerbillus, Arvicanthis niloticus and Rattus rattus, while in kidney, the SOD depletion did not appear except of Rattus rattus. Consistently, bromadiolone exposure reduced SOD in erythrocyte and liver of birds (Sodhi et al, 2017).…”

Section: Discussionmentioning

confidence: 54%

Relative Toxicity of Rodenticide Coumatetralyl Against Some Dominant Wild Rat Species From Four Cities in Assiut Governorate

2019

Assiut University Journal of Multidisciplinary Scientific Resea

View full text Add to dashboard Cite

Rodents are considered as one of the most important pests in Egyptian agriculture. In most countries warfarin and related compounds of anticoagulants are undoubtedly the most commonly used, but resistance to warfarin has increasingly become a big problem. Coumatetralyl (COM) is a multi-dose anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide. The current study was designed to determine the dominant rodent species in four sites at Assiut Governorate; Manfalut (1), Deirout (2), Abnoub (3) and Assiut (4). Then the LD 50 of COM doses for each dominant species were estimated. In addition, the harmful effects of ¼ COM LD 50 doses on the studied wild rats were determined. Oxidative stress parameters; carbonyl protein (CP), antioxidants such as glutathione (GSH), activities of superoxide dismutase (SOD), and catalase (CAT) were measured in liver, kidney and erythrocytic lysate. Also, prothrombin time (PT), international normal ratio (INR), fibrin degradation product (FDP), clotting time and bleeding time were determined. In addation to the histopathological examination of liver and kidney. The result showed that the dominant species found in the studied four sites were Rattus rattus, Arvicanthis niloticus and Gerbillus gerbillus the LD 50 of COM estimated in these species were 39.34, 35.29 and 42.84 mg /Kg bw, respectively. Generally, there was a significant rise in CP level and a significant decrease in the antioxidant parameters in the most samples from COM-treated species. Furthermore, the present study showed a significant increase in INR, PTT, clotting time and bleeding 88

show abstract

Section: Discussionmentioning

confidence: 54%